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Novel biologics targeting the P2X7 ion channel.
Koch-Nolte F, Eichhoff A, Pinto-Espinoza C, Schwarz N, Schäfer T, Menzel S, Haag F, Demeules M, Gondé H, Adriouch S. Koch-Nolte F, et al. Curr Opin Pharmacol. 2019 Aug;47:110-118. doi: 10.1016/j.coph.2019.03.001. Epub 2019 Apr 12. Curr Opin Pharmacol. 2019. PMID: 30986625 Review.
Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers.
Koch K, Kalusche S, Torres JL, Stanfield RL, Danquah W, Khazanehdari K, von Briesen H, Geertsma ER, Wilson IA, Wernery U, Koch-Nolte F, Ward AB, Dietrich U. Koch K, et al. Sci Rep. 2017 Aug 21;7(1):8390. doi: 10.1038/s41598-017-08273-7. Sci Rep. 2017. PMID: 28827559 Free PMC article.
Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo.
Fumey W, Koenigsdorf J, Kunick V, Menzel S, Schütze K, Unger M, Schriewer L, Haag F, Adam G, Oberle A, Binder M, Fliegert R, Guse A, Zhao YJ, Cheung Lee H, Malavasi F, Goldbaum F, van Hegelsom R, Stortelers C, Bannas P, Koch-Nolte F. Fumey W, et al. Sci Rep. 2017 Oct 30;7(1):14289. doi: 10.1038/s41598-017-14112-6. Sci Rep. 2017. PMID: 29084989 Free PMC article.
Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT.
Unger M, Eichhoff AM, Schumacher L, Strysio M, Menzel S, Schwan C, Alzogaray V, Zylberman V, Seman M, Brandner J, Rohde H, Zhu K, Haag F, Mittrücker HW, Goldbaum F, Aktories K, Koch-Nolte F. Unger M, et al. Sci Rep. 2015 Jan 19;5:7850. doi: 10.1038/srep07850. Sci Rep. 2015. PMID: 25597743 Free PMC article.
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