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Synthesis, carbonic anhydrase I and II isoenzymes inhibition properties, and antibacterial activities of novel tetralone-based 1,4-benzothiazepine derivatives.
Ceylan M, Kocyigit UM, Usta NC, Gürbüzlü B, Temel Y, Alwasel SH, Gülçin İ. Ceylan M, et al. J Biochem Mol Toxicol. 2017 Apr;31(4). doi: 10.1002/jbt.21872. Epub 2016 Oct 25. J Biochem Mol Toxicol. 2017. PMID: 27780313
Also, benzothiazepine derivative 7 showed the best hCA II inhibitory effect with K(i) value of 11.31 nM. On the other hand, acetazolamide clinically used as CA inhibitor, showed K(i) value of 19.92 nM against hCA I and 33.60 nM against hCA II, respectively....
Also, benzothiazepine derivative 7 showed the best hCA II inhibitory effect with K(i) value of 11.31 nM. On the other hand, acetazola …
Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(α-aminoalkyl)phosphinic acid derivatives against human breast cancer.
Dastan T, Kocyigit UM, Durna Dastan S, Canturk Kilickaya P, Taslimi P, Cevik O, Koparir M, Orek C, Gulçin İ, Cetin A. Dastan T, et al. J Biochem Mol Toxicol. 2017 Nov;31(11). doi: 10.1002/jbt.21971. Epub 2017 Aug 17. J Biochem Mol Toxicol. 2017. PMID: 28833991