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Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.
Koh CY, Kim JE, Wetzel AB, de van der Schueren WJ, Shibata S, Ranade RM, Liu J, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. Koh CY, et al. PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2775. doi: 10.1371/journal.pntd.0002775. eCollection 2014 Apr. PLoS Negl Trop Dis. 2014. PMID: 24743796 Free PMC article.
Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.
Pedró-Rosa L, Buckner FS, Ranade RM, Eberhart C, Madoux F, Gillespie JR, Koh CY, Brown S, Lohse J, Verlinde CL, Fan E, Bannister T, Scampavia L, Hol WG, Spicer T, Hodder P. Pedró-Rosa L, et al. Among authors: koh cy. J Biomol Screen. 2015 Jan;20(1):122-30. doi: 10.1177/1087057114548832. Epub 2014 Aug 27. J Biomol Screen. 2015. PMID: 25163684 Free PMC article.
5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Zhang Z, Koh CY, Ranade RM, Shibata S, Gillespie JR, Hulverson MA, Huang W, Nguyen J, Pendem N, Gelb MH, Verlinde CL, Hol WG, Buckner FS, Fan E. Zhang Z, et al. Among authors: koh cy. ACS Infect Dis. 2016 Jun 10;2(6):399-404. doi: 10.1021/acsinfecdis.6b00036. Epub 2016 Apr 11. ACS Infect Dis. 2016. PMID: 27627628 Free PMC article.
Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
Huang W, Zhang Z, Barros-Álvarez X, Koh CY, Ranade RM, Gillespie JR, Creason SA, Shibata S, Verlinde CLMJ, Hol WGJ, Buckner FS, Fan E. Huang W, et al. Among authors: koh cy. Eur J Med Chem. 2016 Nov 29;124:1081-1092. doi: 10.1016/j.ejmech.2016.10.024. Epub 2016 Oct 14. Eur J Med Chem. 2016. PMID: 27788467 Free PMC article.
Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.
Barros-Álvarez X, Kerchner KM, Koh CY, Turley S, Pardon E, Steyaert J, Ranade RM, Gillespie JR, Zhang Z, Verlinde CLMJ, Fan E, Buckner FS, Hol WGJ. Barros-Álvarez X, et al. Among authors: koh cy. Biochimie. 2017 Jul;138:124-136. doi: 10.1016/j.biochi.2017.04.006. Epub 2017 Apr 18. Biochimie. 2017. PMID: 28427904 Free PMC article.
97 results