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Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.
Ito I, Tanabe S, Kohda A, Sugiyama H. Ito I, et al. J Physiol. 1990 May;424:533-43. doi: 10.1113/jphysiol.1990.sp018081. J Physiol. 1990. PMID: 1975272 Free PMC article.
Allosteric potentiation of the ionotropic quisqualate (iQA) receptor by a nootropic drug aniracetam (1-p-anisoyl-2-pyrrolidinone) was investigated using Xenopus oocytes injected with rat brain mRNA and rat hippocampal slices. 2. Aniracetam potentiates the iQA responses ind …
Allosteric potentiation of the ionotropic quisqualate (iQA) receptor by a nootropic drug aniracetam (1-p-anisoyl-2-pyrrolidinone) was …
3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors.
Ito I, Kohda A, Tanabe S, Hirose E, Hayashi M, Mitsunaga S, Sugiyama H. Ito I, et al. Neuroreport. 1992 Nov;3(11):1013-6. Neuroreport. 1992. PMID: 1362358
In hippocampal slices, DHPG produced slow excitation of pyramidal cells, resulting from a depression of Ca(2+)-dependent K+ current and a voltage-dependent K+ current. These results indicate that DHPG is a specific and potent agonist of mGluRs....
In hippocampal slices, DHPG produced slow excitation of pyramidal cells, resulting from a depression of Ca(2+)-dependent K+ current a …
A novel dibenzoxazepine derivative (BY-1949) increases regional cerebral blood flow.
Sugawa M, Koide T, Kohda A, Takato M. Sugawa M, et al. Eur J Pharmacol. 1990 Mar 20;178(2):225-8. doi: 10.1016/0014-2999(90)90485-o. Eur J Pharmacol. 1990. PMID: 2328763
The effects of BY-1949, a novel dibenzoxazepine derivative, on the regional cerebral blood flow were investigated in conscious cats. Oral administration of BY-1949 (10-50 mg/kg) significantly increased in a dose-related manner the regional cerebral blood flow in all …
The effects of BY-1949, a novel dibenzoxazepine derivative, on the regional cerebral blood flow were investigated in conscious cats. …
The common marmoset (Callithrix jacchus) as a model for neuroleptic-induced acute dystonia.
Fukuoka T, Nakano M, Kohda A, Okuno Y, Matsuo M. Fukuoka T, et al. Pharmacol Biochem Behav. 1997 Dec;58(4):947-53. doi: 10.1016/s0091-3057(97)00314-6. Pharmacol Biochem Behav. 1997. PMID: 9408199
To examine whether acute dystonia is induced by neuroleptic treatment, common marmosets were treated with haloperidol orally twice a week over 25 weeks until dystonic behavior was elicited. ...Then, various neuroleptic drugs (bromperidol, chlorpromazine, risperidone thiori …
To examine whether acute dystonia is induced by neuroleptic treatment, common marmosets were treated with haloperidol orally twice a
Application of computer-assisted sperm analysis system to elucidate lack of effects of cyclophosphamide on rat epididymal sperm motion.
Higuchi H, Nakaoka M, Kawamura S, Kamita Y, Kohda A, Seki T. Higuchi H, et al. J Toxicol Sci. 2001 May;26(2):75-83. doi: 10.2131/jts.26.75. J Toxicol Sci. 2001. PMID: 11429970
A computer-assisted sperm analysis (CASA) system was used to examine the motion of epididymal spermatozoa derived from cyclophosphamide (CP)-treated male rats. ...
A computer-assisted sperm analysis (CASA) system was used to examine the motion of epididymal spermatozoa derived from cyclophosphami
Chronic effects of a novel synthetic anthracycline derivative (SM-5887) on normal heart and doxorubicin-induced cardiomyopathy in beagle dogs.
Noda T, Watanabe T, Kohda A, Hosokawa S, Suzuki T. Noda T, et al. Invest New Drugs. 1998;16(2):121-8. doi: 10.1023/a:1006088907271. Invest New Drugs. 1998. PMID: 9848575
In the chronic treatment, beagle dogs of each sex were given intravenously once every 3 weeks, either a sublethal dose of doxorubicin (1.5 mg/kg) or SM-5887 (2.5 mg/kg). ...To examine a possibly deteriorating cardiotoxic effect of SM-5887, low-grade cardiomyopathy w …
In the chronic treatment, beagle dogs of each sex were given intravenously once every 3 weeks, either a sublethal dose of doxorubicin …
Replication timing properties within the mouse distal chromosome 7 imprinting cluster.
Kagotani K, Takebayashi S, Kohda A, Taguchi H, Paulsen M, Walter J, Reik W, Okumura K. Kagotani K, et al. Biosci Biotechnol Biochem. 2002 May;66(5):1046-51. doi: 10.1271/bbb.66.1046. Biosci Biotechnol Biochem. 2002. PMID: 12092814
Treatment of the cells with a histone deacetylase inhibitor abolished this allele-specific feature accompanied with accelerated replication of the later-replicating allele at a domain level. ...These results suggest that this imprinting cluster consists of a
Treatment of the cells with a histone deacetylase inhibitor abolished this allele-specific feature accompanied with accelerated repli …
Visualization of transcription-dependent association of imprinted genes with the nuclear matrix.
Kagotani K, Nabeshima H, Kohda A, Nakao M, Taguchi H, Okumura K. Kagotani K, et al. Exp Cell Res. 2002 Apr 1;274(2):189-96. doi: 10.1006/excr.2002.5478. Exp Cell Res. 2002. PMID: 11900479
Genomic imprinting is characterized by allele-specific gene expression as a biological phenomenon. To analyze the participation of the nuclear matrix in the expression of imprinted genes, we first examined the allelic expression state of genes by simultaneously visualizing …
Genomic imprinting is characterized by allele-specific gene expression as a biological phenomenon. To analyze the participation of th …
Visualization of biallelic expression of the imprinted SNRPN gene induced by inhibitors of DNA methylation and histone deacetylation.
Kohda A, Taguchi H, Okumura K. Kohda A, et al. Biosci Biotechnol Biochem. 2001 May;65(5):1236-9. doi: 10.1271/bbb.65.1236. Biosci Biotechnol Biochem. 2001. PMID: 11440148
We have adapted a fluorescence in situ hybridization (FISH) method to detect nascent RNA molecules of the imprinted SNRPN gene at the initial transcription sites in nuclei of human HL60 and WI38 cells. ...
We have adapted a fluorescence in situ hybridization (FISH) method to detect nascent RNA molecules of the imprinted SNRPN gene at the …
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