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1,406 results
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ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA.
Fujishiro SH, Tanimura S, Mure S, Kashimoto Y, Watanabe K, Kohno M. Fujishiro SH, et al. Among authors: kohno m. Biochem Biophys Res Commun. 2008 Mar 28;368(1):162-7. doi: 10.1016/j.bbrc.2008.01.066. Epub 2008 Jan 22. Biochem Biophys Res Commun. 2008. PMID: 18211802
Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes.
Ozaki KI, Awazu M, Tamiya M, Iwasaki Y, Harada A, Kugisaki S, Tanimura S, Kohno M. Ozaki KI, et al. Among authors: kohno m. Am J Physiol Endocrinol Metab. 2016 Apr 15;310(8):E643-E651. doi: 10.1152/ajpendo.00445.2015. Epub 2016 Feb 9. Am J Physiol Endocrinol Metab. 2016. PMID: 26860984
GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability.
Kakiashvili E, Speight P, Waheed F, Seth R, Lodyga M, Tanimura S, Kohno M, Rotstein OD, Kapus A, Szászi K. Kakiashvili E, et al. Among authors: kohno m. J Biol Chem. 2009 Apr 24;284(17):11454-66. doi: 10.1074/jbc.M805933200. Epub 2009 Mar 3. J Biol Chem. 2009. PMID: 19261619 Free PMC article.
Up-regulation of pro-apoptotic protein Bim and down-regulation of anti-apoptotic protein Mcl-1 cooperatively mediate enhanced tumor cell death induced by the combination of ERK kinase (MEK) inhibitor and microtubule inhibitor.
Kawabata T, Tanimura S, Asai K, Kawasaki R, Matsumaru Y, Kohno M. Kawabata T, et al. Among authors: kohno m. J Biol Chem. 2012 Mar 23;287(13):10289-300. doi: 10.1074/jbc.M111.319426. Epub 2012 Jan 23. J Biol Chem. 2012. PMID: 22270368 Free PMC article.
Activation of protein phosphatase causes alternative splicing of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): potential effect on immune surveillance.
Kamachi M, Aramaki T, Tanimura S, Ichinose K, Fujikawa K, Iwamoto N, Yoshizaki A, Ida H, Kawakami A, Kohno M, Eguchi K. Kamachi M, et al. Among authors: kohno m. Biochem Biophys Res Commun. 2007 Aug 17;360(1):280-5. doi: 10.1016/j.bbrc.2007.06.046. Epub 2007 Jun 15. Biochem Biophys Res Commun. 2007. PMID: 17583676
SH3P2 is a negative regulator of cell motility whose function is inhibited by ribosomal S6 kinase-mediated phosphorylation.
Tanimura S, Hashizume J, Kurosaki Y, Sei K, Gotoh A, Ohtake R, Kawano M, Watanabe K, Kohno M. Tanimura S, et al. Among authors: kohno m. Genes Cells. 2011 May;16(5):514-26. doi: 10.1111/j.1365-2443.2011.01503.x. Epub 2011 Apr 18. Genes Cells. 2011. PMID: 21501342
Histone deacetylase inhibitors enhance the chemosensitivity of tumor cells with cross-resistance to a wide range of DNA-damaging drugs.
Ozaki K, Kishikawa F, Tanaka M, Sakamoto T, Tanimura S, Kohno M. Ozaki K, et al. Among authors: kohno m. Cancer Sci. 2008 Feb;99(2):376-84. doi: 10.1111/j.1349-7006.2007.00669.x. Epub 2008 Jan 15. Cancer Sci. 2008. PMID: 18201278
Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells.
Tanimura S, Hirano AI, Hashizume J, Yasunaga M, Kawabata T, Ozaki K, Kohno M. Tanimura S, et al. Among authors: kohno m. J Biol Chem. 2007 Dec 7;282(49):35430-9. doi: 10.1074/jbc.M707547200. Epub 2007 Sep 12. J Biol Chem. 2007. PMID: 17855353
Suppression of tumor cell invasiveness by hydrolyzable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity.
Tanimura S, Kadomoto R, Tanaka T, Zhang YJ, Kouno I, Kohno M. Tanimura S, et al. Among authors: kohno m. Biochem Biophys Res Commun. 2005 May 20;330(4):1306-13. doi: 10.1016/j.bbrc.2005.03.116. Biochem Biophys Res Commun. 2005. PMID: 15823585
ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips.
Tanimura S, Hashizume J, Arichika N, Watanabe K, Ohyama K, Takeda K, Kohno M. Tanimura S, et al. Among authors: kohno m. J Cell Biol. 2016 Aug 15;214(4):475-89. doi: 10.1083/jcb.201503123. Epub 2016 Aug 8. J Cell Biol. 2016. PMID: 27502487 Free PMC article.
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