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p53 orchestrates between normal differentiation and cancer.
Rivlin N, Koifman G, Rotter V. Rivlin N, et al. Among authors: koifman g. Semin Cancer Biol. 2015 Jun;32:10-7. doi: 10.1016/j.semcancer.2013.12.006. Epub 2014 Jan 7. Semin Cancer Biol. 2015. PMID: 24406212 Review.
Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation.
Rivlin N, Katz S, Doody M, Sheffer M, Horesh S, Molchadsky A, Koifman G, Shetzer Y, Goldfinger N, Rotter V, Geiger T. Rivlin N, et al. Among authors: koifman g. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7006-11. doi: 10.1073/pnas.1320428111. Epub 2014 Apr 28. Proc Natl Acad Sci U S A. 2014. PMID: 24778235 Free PMC article.
The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele.
Shetzer Y, Kagan S, Koifman G, Sarig R, Kogan-Sakin I, Charni M, Kaufman T, Zapatka M, Molchadsky A, Rivlin N, Dinowitz N, Levin S, Landan G, Goldstein I, Goldfinger N, Pe'er D, Radlwimmer B, Lichter P, Rotter V, Aloni-Grinstein R. Shetzer Y, et al. Among authors: koifman g. Cell Death Differ. 2014 Sep;21(9):1419-31. doi: 10.1038/cdd.2014.57. Epub 2014 May 16. Cell Death Differ. 2014. PMID: 24832469 Free PMC article.
Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.
Solomon H, Dinowitz N, Pateras IS, Cooks T, Shetzer Y, Molchadsky A, Charni M, Rabani S, Koifman G, Tarcic O, Porat Z, Kogan-Sakin I, Goldfinger N, Oren M, Harris CC, Gorgoulis VG, Rotter V. Solomon H, et al. Among authors: koifman g. Oncogene. 2018 Mar;37(12):1669-1684. doi: 10.1038/s41388-017-0060-8. Epub 2018 Jan 18. Oncogene. 2018. PMID: 29343849 Free PMC article.
p53 balances between tissue hierarchy and anarchy.
Koifman G, Aloni-Grinstein R, Rotter V. Koifman G, et al. J Mol Cell Biol. 2019 Jul 19;11(7):553-563. doi: 10.1093/jmcb/mjz022. J Mol Cell Biol. 2019. PMID: 30925590 Free PMC article. Review.
15 results