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The Ku70-binding site of Ku80 is required for the stabilization of Ku70 in the cytoplasm, for the nuclear translocation of Ku80, and for Ku80-dependent DNA repair.
Koike M, Koike A. Koike M, et al. Exp Cell Res. 2005 May 1;305(2):266-76. doi: 10.1016/j.yexcr.2004.12.027. Exp Cell Res. 2005. PMID: 15817152
In addition, our results suggest that the nuclear translocation of Ku80 through the Ku70-binding site as well as through the NLS of Ku80 play, at least in part, a role in Ku80-dependent DNA repair. Furthermore, our results suggest the possibility that Ku80 has a DNA …
In addition, our results suggest that the nuclear translocation of Ku80 through the Ku70-binding site as well as through the NLS of Ku80 pla …
Cloning of canine Ku80 and its localization and accumulation at DNA damage sites.
Koike M, Yutoku Y, Koike A. Koike M, et al. FEBS Open Bio. 2017 Nov 2;7(12):1854-1863. doi: 10.1002/2211-5463.12311. eCollection 2017 Dec. FEBS Open Bio. 2017. PMID: 29226073 Free PMC article.
However, their antitumor effect might be greatly diminished by variation in even a single amino acid in the target site, as it occurs, for example, as a consequence of SNPs. ...
However, their antitumor effect might be greatly diminished by variation in even a single amino acid in the target site, as it occurs …
Cloning, localization and focus formation at DNA damage sites of canine Ku70.
Koike M, Yutoku Y, Koike A. Koike M, et al. J Vet Med Sci. 2017 Mar 23;79(3):554-561. doi: 10.1292/jvms.16-0649. Epub 2017 Feb 6. J Vet Med Sci. 2017. PMID: 28163277 Free PMC article.
Structurally, two DNA-PK phosphorylation sites (S6 and S51), an ubiquitination site (K114), two canonical sumoylation consensus motifs, a CDK phosphorylation motif, and a nuclear localization signal (NLS) in the human Ku70 are evolutionarily conserved in canine and …
Structurally, two DNA-PK phosphorylation sites (S6 and S51), an ubiquitination site (K114), two canonical sumoylation consensus motifs, a
Cloning, localization and focus formation at DNA damage sites of canine XRCC4.
Koike M, Yutoku Y, Koike A. Koike M, et al. J Vet Med Sci. 2017 Jan 10;78(12):1865-1871. doi: 10.1292/jvms.16-0381. Epub 2016 Sep 18. J Vet Med Sci. 2017. PMID: 27644316 Free PMC article.
XRCC4 plays a critical role in Ku-dependent nonhomologous DNA-end joining (NHEJ) in human cells, and is one of the core NHEJ factors. The localization of core NHEJ factors, such as human Ku70 and Ku80, might play a crucial role in regulating NHEJ activity. Recently, …
XRCC4 plays a critical role in Ku-dependent nonhomologous DNA-end joining (NHEJ) in human cells, and is one of the core NHEJ factors. …
Cloning, localization and focus formation at DNA damage sites of canine XLF.
Koike M, Yutoku Y, Koike A. Koike M, et al. J Vet Med Sci. 2017 Jan 20;79(1):22-28. doi: 10.1292/jvms.16-0440. Epub 2016 Oct 14. J Vet Med Sci. 2017. PMID: 27746407 Free PMC article.
XRCC4-like factor (XLF) is a core NHEJ factor and plays a key role in the Ku-dependent NHEJ repair process in human cells. Recently, companion animals, such as canines, have been proposed to be a good model for many aspects of cancer research, including the d …
XRCC4-like factor (XLF) is a core NHEJ factor and plays a key role in the Ku-dependent NHEJ repair process in human cells. Rec …
The C-terminal region of Rad52 is essential for Rad52 nuclear and nucleolar localization, and accumulation at DNA damage sites immediately after irradiation.
Koike M, Yutoku Y, Koike A. Koike M, et al. Biochem Biophys Res Commun. 2013 May 31;435(2):260-6. doi: 10.1016/j.bbrc.2013.04.067. Epub 2013 Apr 30. Biochem Biophys Res Commun. 2013. PMID: 23639616
Rad52 localizes in the nucleus and forms foci at a late stage following irradiation. Ku70 and Ku80, which play an essential role in nonhomologous DNA-end-joining (NHEJ), are essential for the accumulation of other core NHEJ factors, e.g., XRCC4, and a HR-related fac …
Rad52 localizes in the nucleus and forms foci at a late stage following irradiation. Ku70 and Ku80, which play an essential role in n …
The defect of Ku70 affects sensitivity to x-ray and radiation-induced caspase-dependent apoptosis in lung cells.
Koike M, Yutoku Y, Koike A. Koike M, et al. J Vet Med Sci. 2013 May 2;75(4):415-20. doi: 10.1292/jvms.12-0333. Epub 2012 Nov 14. J Vet Med Sci. 2013. PMID: 23149547
We also examined the expression level of phosphorylated H2AX (γH2AX), which is a marker of DSB, and observed the phosphorylation of H2AX and the elimination of γH2AX in both cell lines after X-irradiation. ...These findings suggest that Ku70 might play a key role in …
We also examined the expression level of phosphorylated H2AX (γH2AX), which is a marker of DSB, and observed the phosphorylation of H …
Establishment of hamster cell lines with EGFP-tagged human XRCC4 and protection from low-dose X-ray radiation.
Koike M, Yutoku Y, Koike A. Koike M, et al. J Vet Med Sci. 2012 Oct;74(10):1269-75. doi: 10.1292/jvms.12-0112. Epub 2012 May 23. J Vet Med Sci. 2012. PMID: 22673749
The DNA repair protein XRCC4, which is a regulator of DNA ligase IV activity, might be a key contributor to not only chemoresistance to anticancer agents, e.g., etoposide, but also radioresistance. However, it remains unclear whether XRCC4, which is a key pla …
The DNA repair protein XRCC4, which is a regulator of DNA ligase IV activity, might be a key contributor to not only chemoresi …
Accumulation of Ku70 at DNA double-strand breaks in living epithelial cells.
Koike M, Yutoku Y, Koike A. Koike M, et al. Exp Cell Res. 2011 Oct 15;317(17):2429-37. doi: 10.1016/j.yexcr.2011.07.018. Epub 2011 Jul 29. Exp Cell Res. 2011. PMID: 21820429
Accumulation of p21 proteins at DNA damage sites independent of p53 and core NHEJ factors following irradiation.
Koike M, Yutoku Y, Koike A. Koike M, et al. Biochem Biophys Res Commun. 2011 Aug 19;412(1):39-43. doi: 10.1016/j.bbrc.2011.07.032. Epub 2011 Jul 20. Biochem Biophys Res Commun. 2011. PMID: 21787748
., cell cycle checkpoints, senescence, or apoptosis. p21 might also play a role in DNA repair. p21 foci arise at heavy-ion-irradiated DNA-double-strand break (DSB) sites, which are mainly repaired by nonhomologous DNA-end-joining (NHEJ). ...These findings also suggest that …
., cell cycle checkpoints, senescence, or apoptosis. p21 might also play a role in DNA repair. p21 foci arise at heavy-ion-irradiated …
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