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An effective interferon-gamma-mediated inhibition of hepatitis C virus replication by natural killer cells is associated with spontaneous clearance of acute hepatitis C in human immunodeficiency virus-positive patients.
Kokordelis P, Krämer B, Körner C, Boesecke C, Voigt E, Ingiliz P, Glässner A, Eisenhardt M, Wolter F, Kaczmarek D, Nischalke HD, Rockstroh JK, Spengler U, Nattermann J. Kokordelis P, et al. Hepatology. 2014 Mar;59(3):814-27. doi: 10.1002/hep.26782. Epub 2014 Jan 21. Hepatology. 2014. PMID: 24382664
Hypoxia impairs anti-viral activity of natural killer (NK) cells but has little effect on anti-fibrotic NK cell functions in hepatitis C virus infection.
Wolter F, Glässner A, Krämer B, Kokordelis P, Finnemann C, Kaczmarek DJ, Goeser F, Lutz P, Nischalke HD, Strassburg CP, Spengler U, Nattermann J. Wolter F, et al. Among authors: kokordelis p. J Hepatol. 2015 Dec;63(6):1334-44. doi: 10.1016/j.jhep.2015.08.008. Epub 2015 Aug 20. J Hepatol. 2015. PMID: 26297916
Alterations of the NK cell pool in HIV/HCV co-infection.
Kaczmarek DJ, Kokordelis P, Krämer B, Glässner A, Wolter F, Goeser F, Lutz P, Schwarze-Zander C, Boesecke C, Strassburg CP, Rockstroh JK, Spengler U, Nattermann J. Kaczmarek DJ, et al. Among authors: kokordelis p. PLoS One. 2017 Apr 5;12(4):e0174465. doi: 10.1371/journal.pone.0174465. eCollection 2017. PLoS One. 2017. PMID: 28380039 Free PMC article.
The CXCR3(+)CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C.
Eisenhardt M, Glässner A, Krämer B, Körner C, Sibbing B, Kokordelis P, Nischalke HD, Sauerbruch T, Spengler U, Nattermann J. Eisenhardt M, et al. Among authors: kokordelis p. PLoS One. 2012;7(7):e38846. doi: 10.1371/journal.pone.0038846. Epub 2012 Jul 5. PLoS One. 2012. PMID: 22792160 Free PMC article.
16 results