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The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway.
Spagnol V, Oliveira CAB, Randle SJ, Passos PMS, Correia CRSTB, Simaroli NB, Oliveira JS, Mevissen TET, Medeiros AC, Gomes MD, Komander D, Laman H, Teixeira FR. Spagnol V, et al. Among authors: komander d. Biochim Biophys Acta Gen Subj. 2020 Sep 30;1865(1):129754. doi: 10.1016/j.bbagen.2020.129754. Online ahead of print. Biochim Biophys Acta Gen Subj. 2020. PMID: 33010352
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
Klemm T, Ebert G, Calleja DJ, Allison CC, Richardson LW, Bernardini JP, Lu BG, Kuchel NW, Grohmann C, Shibata Y, Gan ZY, Cooney JP, Doerflinger M, Au AE, Blackmore TR, van der Heden van Noort GJ, Geurink PP, Ovaa H, Newman J, Riboldi-Tunnicliffe A, Czabotar PE, Mitchell JP, Feltham R, Lechtenberg BC, Lowes KN, Dewson G, Pellegrini M, Lessene G, Komander D. Klemm T, et al. Among authors: komander d. EMBO J. 2020 Aug 26;39(18):e106275. doi: 10.15252/embj.2020106275. Online ahead of print. EMBO J. 2020. PMID: 32845033 Free PMC article.
Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression.
Visser LJ, Aloise C, Swatek KN, Medina GN, Olek KM, Rabouw HH, de Groot RJ, Langereis MA, de Los Santos T, Komander D, Skern T, van Kuppeveld FJM. Visser LJ, et al. Among authors: komander d. PLoS Pathog. 2020 Jul 15;16(7):e1008702. doi: 10.1371/journal.ppat.1008702. eCollection 2020 Jul. PLoS Pathog. 2020. PMID: 32667958 Free PMC article.
USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A, Martinez A, Marcassa E, Gersch M, Buckmelter AJ, Kayser-Bricker KJ, Lamoliatte F, Gajbhiye A, Davis S, Scott HC, Murphy E, England K, Mortiboys H, Komander D, Trost M, Kessler BM, Ioannidis S, Ahlijanian MK, Urbé S, Clague MJ. Rusilowicz-Jones EV, et al. Among authors: komander d. Life Sci Alliance. 2020 Jul 7;3(8):e202000768. doi: 10.26508/lsa.202000768. Print 2020 Aug. Life Sci Alliance. 2020. PMID: 32636217 Free PMC article.
Identification and characterization of diverse OTU deubiquitinases in bacteria.
Schubert AF, Nguyen JV, Franklin TG, Geurink PP, Roberts CG, Sanderson DJ, Miller LN, Ovaa H, Hofmann K, Pruneda JN, Komander D. Schubert AF, et al. Among authors: komander d. EMBO J. 2020 Aug 3;39(15):e105127. doi: 10.15252/embj.2020105127. Epub 2020 Jun 22. EMBO J. 2020. PMID: 32567101 Free PMC article.
The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.
Alix E, Godlee C, Cerny O, Blundell S, Tocci R, Matthews S, Liu M, Pruneda JN, Swatek KN, Komander D, Sleap T, Holden DW. Alix E, et al. Among authors: komander d. Cell Host Microbe. 2020 Jul 8;28(1):54-68.e7. doi: 10.1016/j.chom.2020.04.024. Epub 2020 Jun 10. Cell Host Microbe. 2020. PMID: 32526160 Free PMC article.
OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer.
Damgaard RB, Jolin HE, Allison MED, Davies SE, Titheradge HL, McKenzie ANJ, Komander D. Damgaard RB, et al. Among authors: komander d. Cell Death Differ. 2020 May;27(5):1457-1474. doi: 10.1038/s41418-020-0532-1. Epub 2020 Mar 30. Cell Death Differ. 2020. PMID: 32231246 Free PMC article.
Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling.
Ordureau A, Paulo JA, Zhang J, An H, Swatek KN, Cannon JR, Wan Q, Komander D, Harper JW. Ordureau A, et al. Among authors: komander d. Mol Cell. 2020 Mar 5;77(5):1124-1142.e10. doi: 10.1016/j.molcel.2019.11.013. Mol Cell. 2020. PMID: 32142685 Free PMC article.
Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation.
Schuster R, Anton V, Simões T, Altin S, den Brave F, Hermanns T, Hospenthal M, Komander D, Dittmar G, Dohmen RJ, Escobar-Henriques M. Schuster R, et al. Among authors: komander d. Life Sci Alliance. 2019 Dec 19;3(1):e201900476. doi: 10.26508/lsa.201900476. Print 2020 Jan. Life Sci Alliance. 2019. PMID: 31857350 Free PMC article.
Regulation of the endosomal SNX27-retromer by OTULIN.
Stangl A, Elliott PR, Pinto-Fernandez A, Bonham S, Harrison L, Schaub A, Kutzner K, Keusekotten K, Pfluger PT, El Oualid F, Kessler BM, Komander D, Krappmann D. Stangl A, et al. Among authors: komander d. Nat Commun. 2019 Sep 20;10(1):4320. doi: 10.1038/s41467-019-12309-z. Nat Commun. 2019. PMID: 31541095 Free PMC article.
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