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Breaking the chains: structure and function of the deubiquitinases.
Komander D, Clague MJ, Urbé S. Komander D, et al. Nat Rev Mol Cell Biol. 2009 Aug;10(8):550-63. doi: 10.1038/nrm2731. Nat Rev Mol Cell Biol. 2009. PMID: 19626045 Review.
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.
Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S, Dikic I. Rahighi S, et al. Cell. 2009 Mar 20;136(6):1098-109. doi: 10.1016/j.cell.2009.03.007. Cell. 2009. PMID: 19303852
Dissection of USP catalytic domains reveals five common insertion points.
Ye Y, Scheel H, Hofmann K, Komander D. Ye Y, et al. Mol Biosyst. 2009 Dec;5(12):1797-808. doi: 10.1039/b907669g. Epub 2009 Jul 17. Mol Biosyst. 2009. PMID: 19734957
The emerging complexity of protein ubiquitination.
Komander D. Komander D. Biochem Soc Trans. 2009 Oct;37(Pt 5):937-53. doi: 10.1042/BST0370937. Biochem Soc Trans. 2009. PMID: 19754430 Review.
Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.
Kulathu Y, Akutsu M, Bremm A, Hofmann K, Komander D. Kulathu Y, et al. Nat Struct Mol Biol. 2009 Dec;16(12):1328-30. doi: 10.1038/nsmb.1731. Epub 2009 Nov 22. Nat Struct Mol Biol. 2009. PMID: 19935683
The nuts and bolts of AGC protein kinases.
Pearce LR, Komander D, Alessi DR. Pearce LR, et al. Nat Rev Mol Cell Biol. 2010 Jan;11(1):9-22. doi: 10.1038/nrm2822. Nat Rev Mol Cell Biol. 2010. PMID: 20027184 Review.
CYLD tidies up dishevelled signaling.
Komander D. Komander D. Mol Cell. 2010 Mar 12;37(5):589-90. doi: 10.1016/j.molcel.2010.02.017. Mol Cell. 2010. PMID: 20227361
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