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The nuts and bolts of AGC protein kinases.
Pearce LR, Komander D, Alessi DR. Pearce LR, et al. Among authors: komander d. Nat Rev Mol Cell Biol. 2010 Jan;11(1):9-22. doi: 10.1038/nrm2822. Nat Rev Mol Cell Biol. 2010. PMID: 20027184 Review.
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.
Biondi RM, Komander D, Thomas CC, Lizcano JM, Deak M, Alessi DR, van Aalten DM. Biondi RM, et al. Among authors: komander d. EMBO J. 2002 Aug 15;21(16):4219-28. doi: 10.1093/emboj/cdf437. EMBO J. 2002. PMID: 12169624 Free PMC article.
Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.
Komander D, Kular GS, Bain J, Elliott M, Alessi DR, Van Aalten DM. Komander D, et al. Biochem J. 2003 Oct 15;375(Pt 2):255-62. doi: 10.1042/BJ20031119. Biochem J. 2003. PMID: 12892559 Free PMC article.
Purification, crystallization and preliminary X-ray diffraction of a proteolytic fragment of PDK1 containing the pleckstrin homology domain.
Komander D, Deak M, Morrice N, van Aalten DM. Komander D, et al. Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):314-6. doi: 10.1107/S0907444903028518. Epub 2004 Jan 23. Acta Crystallogr D Biol Crystallogr. 2004. PMID: 14747709
Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1.
Komander D, Kular GS, Schüttelkopf AW, Deak M, Prakash KR, Bain J, Elliott M, Garrido-Franco M, Kozikowski AP, Alessi DR, van Aalten DM. Komander D, et al. Structure. 2004 Feb;12(2):215-26. doi: 10.1016/j.str.2004.01.005. Structure. 2004. PMID: 14962382
PDK1, the master regulator of AGC kinase signal transduction.
Mora A, Komander D, van Aalten DM, Alessi DR. Mora A, et al. Among authors: komander d. Semin Cell Dev Biol. 2004 Apr;15(2):161-70. doi: 10.1016/j.semcdb.2003.12.022. Semin Cell Dev Biol. 2004. PMID: 15209375 Review.
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.
Komander D, Fairservice A, Deak M, Kular GS, Prescott AR, Peter Downes C, Safrany ST, Alessi DR, van Aalten DM. Komander D, et al. EMBO J. 2004 Oct 13;23(20):3918-28. doi: 10.1038/sj.emboj.7600379. Epub 2004 Sep 30. EMBO J. 2004. PMID: 15457207 Free PMC article.
Analysis of the LKB1-STRAD-MO25 complex.
Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR. Boudeau J, et al. Among authors: komander d. J Cell Sci. 2004 Dec 15;117(Pt 26):6365-75. doi: 10.1242/jcs.01571. Epub 2004 Nov 23. J Cell Sci. 2004. PMID: 15561763
Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.
Komander D, Kular G, Deak M, Alessi DR, van Aalten DM. Komander D, et al. J Biol Chem. 2005 May 13;280(19):18797-802. doi: 10.1074/jbc.M500977200. Epub 2005 Mar 1. J Biol Chem. 2005. PMID: 15741170
Lining the pockets of kinases and phosphatases.
Gold MG, Barford D, Komander D. Gold MG, et al. Among authors: komander d. Curr Opin Struct Biol. 2006 Dec;16(6):693-701. doi: 10.1016/j.sbi.2006.10.006. Epub 2006 Nov 2. Curr Opin Struct Biol. 2006. PMID: 17084073 Review.
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