Komander D - Search Results

1

On terminal alkynes that can react with active-site cysteine nucleophiles in proteases.

Ekkebus R, van Kasteren SI, Kulathu Y, Scholten A, Berlin I, Geurink PP, de Jong A, Goerdayal S, Neefjes J, Heck AJ, Komander D, Ovaa H. Ekkebus R, et al. Among authors: komander d. J Am Chem Soc. 2013 Feb 27;135(8):2867-70. doi: 10.1021/ja309802n. Epub 2013 Feb 15. J Am Chem Soc. 2013. PMID: 23387960 Free PMC article.

2

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.

Kulathu Y, Akutsu M, Bremm A, Hofmann K, Komander D. Kulathu Y, et al. Among authors: komander d. Nat Struct Mol Biol. 2009 Dec;16(12):1328-30. doi: 10.1038/nsmb.1731. Epub 2009 Nov 22. Nat Struct Mol Biol. 2009. PMID: 19935683

3

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.

Licchesi JD, Mieszczanek J, Mevissen TE, Rutherford TJ, Akutsu M, Virdee S, El Oualid F, Chin JW, Ovaa H, Bienz M, Komander D. Licchesi JD, et al. Among authors: komander d. Nat Struct Mol Biol. 2011 Dec 11;19(1):62-71. doi: 10.1038/nsmb.2169. Nat Struct Mol Biol. 2011. PMID: 22157957 Free PMC article.

4

Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages.

Kulathu Y, Komander D. Kulathu Y, et al. Among authors: komander d. Nat Rev Mol Cell Biol. 2012 Jul 23;13(8):508-23. doi: 10.1038/nrm3394. Nat Rev Mol Cell Biol. 2012. PMID: 22820888 Review.

5

Regulation of A20 and other OTU deubiquitinases by reversible oxidation.

Kulathu Y, Garcia FJ, Mevissen TE, Busch M, Arnaudo N, Carroll KS, Barford D, Komander D. Kulathu Y, et al. Among authors: komander d. Nat Commun. 2013;4:1569. doi: 10.1038/ncomms2567. Nat Commun. 2013. PMID: 23463012 Free PMC article.

6

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin.

Keusekotten K, Elliott PR, Glockner L, Fiil BK, Damgaard RB, Kulathu Y, Wauer T, Hospenthal MK, Gyrd-Hansen M, Krappmann D, Hofmann K, Komander D. Keusekotten K, et al. Among authors: komander d. Cell. 2013 Jun 6;153(6):1312-26. doi: 10.1016/j.cell.2013.05.014. Cell. 2013. PMID: 23746843 Free PMC article.

7

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D. Mevissen TE, et al. Among authors: komander d. Cell. 2013 Jul 3;154(1):169-84. doi: 10.1016/j.cell.2013.05.046. Cell. 2013. PMID: 23827681 Free PMC article.

8

Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes.

Geurink PP, van Tol BD, van Dalen D, Brundel PJ, Mevissen TE, Pruneda JN, Elliott PR, van Tilburg GB, Komander D, Ovaa H. Geurink PP, et al. Among authors: komander d. Chembiochem. 2016 May 3;17(9):816-20. doi: 10.1002/cbic.201600017. Epub 2016 Mar 21. Chembiochem. 2016. PMID: 26996281 Free PMC article.

9

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets.

Flierman D, van der Heden van Noort GJ, Ekkebus R, Geurink PP, Mevissen TE, Hospenthal MK, Komander D, Ovaa H. Flierman D, et al. Among authors: komander d. Cell Chem Biol. 2016 Apr 21;23(4):472-82. doi: 10.1016/j.chembiol.2016.03.009. Epub 2016 Apr 7. Cell Chem Biol. 2016. PMID: 27066941 Free PMC article.

10

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

Mulder MP, Witting K, Berlin I, Pruneda JN, Wu KP, Chang JG, Merkx R, Bialas J, Groettrup M, Vertegaal AC, Schulman BA, Komander D, Neefjes J, El Oualid F, Ovaa H. Mulder MP, et al. Among authors: komander d. Nat Chem Biol. 2016 Jul;12(7):523-30. doi: 10.1038/nchembio.2084. Epub 2016 May 16. Nat Chem Biol. 2016. PMID: 27182664 Free PMC article.

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