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Characterization of feline cytochrome P450 2B6.
Okamatsu G, Komatsu T, Ono Y, Inoue H, Uchide T, Onaga T, Endoh D, Kitazawa T, Hiraga T, Uno Y, Teraoka H. Okamatsu G, et al. Among authors: komatsu t. Xenobiotica. 2017 Feb;47(2):93-102. doi: 10.3109/00498254.2016.1145754. Epub 2016 Mar 9. Xenobiotica. 2017. PMID: 26956662
Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver.
Komatsu T, Yamazaki H, Shimada N, Nagayama S, Kawaguchi Y, Nakajima M, Yokoi T. Komatsu T, et al. Clin Cancer Res. 2001 Mar;7(3):675-81. Clin Cancer Res. 2001. PMID: 11297264
Recently, we have reported that tegafur, an anticancer agent, is biotransformed into active drug 5-fluorouracil (5-FU) by cytochromes P450 1A2, 2A6, and 2C8 in human liver microsomes (T. Komatsu et al., Drug Metab. Dispos, 28: 1457-1463, 2000). Because the conversio …
Recently, we have reported that tegafur, an anticancer agent, is biotransformed into active drug 5-fluorouracil (5-FU) by cytochromes P450 1 …
1,559 results