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71 results
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Translational repression contributes greater noise to gene expression than transcriptional repression.
Komorowski M, Miekisz J, Kierzek AM. Komorowski M, et al. Biophys J. 2009 Jan;96(2):372-84. doi: 10.1016/j.bpj.2008.09.052. Biophys J. 2009. PMID: 19167290 Free PMC article.
Clustering reveals limits of parameter identifiability in multi-parameter models of biochemical dynamics.
Nienałtowski K, Włodarczyk M, Lipniacki T, Komorowski M. Nienałtowski K, et al. Among authors: komorowski m. BMC Syst Biol. 2015 Sep 29;9:65. doi: 10.1186/s12918-015-0205-8. BMC Syst Biol. 2015. PMID: 26415494 Free PMC article.
A hierarchical model of transcriptional dynamics allows robust estimation of transcription rates in populations of single cells with variable gene copy number.
Woodcock DJ, Vance KW, Komorowski M, Koentges G, Finkenstädt B, Rand DA. Woodcock DJ, et al. Among authors: komorowski m. Bioinformatics. 2013 Jun 15;29(12):1519-25. doi: 10.1093/bioinformatics/btt201. Epub 2013 May 14. Bioinformatics. 2013. PMID: 23677939 Free PMC article.
StochDecomp--Matlab package for noise decomposition in stochastic biochemical systems.
Jetka T, Charzyńska A, Gambin A, Stumpf MP, Komorowski M. Jetka T, et al. Among authors: komorowski m. Bioinformatics. 2014 Jan 1;30(1):137-8. doi: 10.1093/bioinformatics/btt631. Epub 2013 Nov 4. Bioinformatics. 2014. PMID: 24191070
Decomposing noise in biochemical signaling systems highlights the role of protein degradation.
Komorowski M, Miękisz J, Stumpf MP. Komorowski M, et al. Biophys J. 2013 Apr 16;104(8):1783-93. doi: 10.1016/j.bpj.2013.02.027. Biophys J. 2013. PMID: 23601325 Free PMC article.
Using a single fluorescent reporter gene to infer half-life of extrinsic noise and other parameters of gene expression.
Komorowski M, Finkenstädt B, Rand D. Komorowski M, et al. Biophys J. 2010 Jun 16;98(12):2759-69. doi: 10.1016/j.bpj.2010.03.032. Biophys J. 2010. PMID: 20550887 Free PMC article.
Reconstruction of transcriptional dynamics from gene reporter data using differential equations.
Finkenstädt B, Heron EA, Komorowski M, Edwards K, Tang S, Harper CV, Davis JR, White MR, Millar AJ, Rand DA. Finkenstädt B, et al. Among authors: komorowski m. Bioinformatics. 2008 Dec 15;24(24):2901-7. doi: 10.1093/bioinformatics/btn562. Epub 2008 Oct 30. Bioinformatics. 2008. PMID: 18974172 Free PMC article.
The Limited Information Capacity of Cross-Reactive Sensors Drives the Evolutionary Expansion of Signaling.
Komorowski M, Tawfik DS. Komorowski M, et al. Cell Syst. 2019 Jan 23;8(1):76-85.e6. doi: 10.1016/j.cels.2018.12.006. Epub 2019 Jan 16. Cell Syst. 2019. PMID: 30660612
StochSens--Matlab package for sensitivity analysis of stochastic chemical systems.
Komorowski M, Zurauskiene J, Stumpf MP. Komorowski M, et al. Bioinformatics. 2012 Mar 1;28(5):731-3. doi: 10.1093/bioinformatics/btr714. Bioinformatics. 2012. PMID: 22378710
Sensitivity, robustness, and identifiability in stochastic chemical kinetics models.
Komorowski M, Costa MJ, Rand DA, Stumpf MP. Komorowski M, et al. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8645-50. doi: 10.1073/pnas.1015814108. Epub 2011 May 6. Proc Natl Acad Sci U S A. 2011. PMID: 21551095 Free PMC article.
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