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A retro-inverso cell-penetrating peptide for siRNA delivery.
Vaissière A, Aldrian G, Konate K, Lindberg MF, Jourdan C, Telmar A, Seisel Q, Fernandez F, Viguier V, Genevois C, Couillaud F, Boisguerin P, Deshayes S. Vaissière A, et al. Among authors: konate k. J Nanobiotechnology. 2017 Apr 28;15(1):34. doi: 10.1186/s12951-017-0269-2. J Nanobiotechnology. 2017. PMID: 28454579 Free PMC article.
However, due to their poor cellular permeability and stability, their therapeutic development requires a specific delivery system. Among them, cell-penetrating peptides (CPP) have been shown to transfer efficiently siRNA inside the cells. Recently we developed amphipathic …
However, due to their poor cellular permeability and stability, their therapeutic development requires a specific delivery system. Among the …
Tips and Tools to Understand Direct Membrane Translocation of siRNA-Loaded WRAP-Based Nanoparticles.
Deshayes S, Konate K, Vivès E, Boisguérin P. Deshayes S, et al. Among authors: konate k. Methods Mol Biol. 2022;2383:475-490. doi: 10.1007/978-1-0716-1752-6_30. Methods Mol Biol. 2022. PMID: 34766308
Cell-penetrating peptide (CPP)-based approaches are excellent method for delivering cell-impermeable compounds/therapeutics such as proteins, antibodies, antisense oligonucleotides, siRNAs, plasmids, and drugs, as covalently or noncovalently conjugated cargo into cells. No …
Cell-penetrating peptide (CPP)-based approaches are excellent method for delivering cell-impermeable compounds/therapeutics such as p …
Structural polymorphism of non-covalent peptide-based delivery systems: highway to cellular uptake.
Deshayes S, Konate K, Aldrian G, Crombez L, Heitz F, Divita G. Deshayes S, et al. Among authors: konate k. Biochim Biophys Acta. 2010 Dec;1798(12):2304-14. doi: 10.1016/j.bbamem.2010.06.005. Epub 2010 Jun 10. Biochim Biophys Acta. 2010. PMID: 20541523 Free article. Review.
Although, several strategies either viral or non viral have been proposed to favor cellular uptake and targeting of therapeutics, only few of them have reach preclinical evaluation. Amongst them, cell-penetrating peptide (CPP) constitutes one of the most promising strategy …
Although, several strategies either viral or non viral have been proposed to favor cellular uptake and targeting of therapeutics, only few o …
Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide.
Konate K, Seisel Q, Vivès E, Boisguérin P, Deshayes S. Konate K, et al. J Vis Exp. 2020 Dec 19;(166). doi: 10.3791/62028. J Vis Exp. 2020. PMID: 33393518
In this article, we present a detailed protocol describing the different steps of a large unilamellar vesicles (LUVs) formulation, purification, characterization, and application in fluorescence leakage assay in order to detect possible CPP-membrane destabilization/interac …
In this article, we present a detailed protocol describing the different steps of a large unilamellar vesicles (LUVs) formulation, purificat …
Optimisation of vectorisation property: A comparative study for a secondary amphipathic peptide.
Konate K, Lindberg MF, Vaissiere A, Jourdan C, Aldrian G, Margeat E, Deshayes S, Boisguerin P. Konate K, et al. Int J Pharm. 2016 Jul 25;509(1-2):71-84. doi: 10.1016/j.ijpharm.2016.05.030. Epub 2016 May 17. Int J Pharm. 2016. PMID: 27224007
In the present work, we have described the parameters influencing CADY nanoparticle formation (buffers, excipients, presence of serum, etc.), and have followed in details the CPP:siRNA self-assembly. Once optimal conditions were determined, we have compared the ability of …
In the present work, we have described the parameters influencing CADY nanoparticle formation (buffers, excipients, presence of serum, etc.) …