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Induction of phase I, II and III drug metabolism/transport by xenobiotics.
Xu C, Li CY, Kong AN. Xu C, et al. Among authors: kong an. Arch Pharm Res. 2005 Mar;28(3):249-68. doi: 10.1007/BF02977789. Arch Pharm Res. 2005. PMID: 15832810 Review.
Along with phase I and phase II enzyme induction, pretreatment with several kinds of inducers has been shown to alter the expression of phase III transporters, and alter the excretion of xenobiotics, which implies that phase III transporters may also be similarly regulated in a c …
Along with phase I and phase II enzyme induction, pretreatment with several kinds of inducers has been shown to alter the expression of phas …
Regulation of Keap1-Nrf2 signaling: The role of epigenetics.
Cheng D, Wu R, Guo Y, Kong AN. Cheng D, et al. Among authors: kong an. Curr Opin Toxicol. 2016 Dec;1:134-138. doi: 10.1016/j.cotox.2016.10.008. Epub 2016 Nov 5. Curr Opin Toxicol. 2016. PMID: 29057383 Free PMC article.
Activation or inhibition of Nrf2 has been an approach to treating many diseases such as cancer and regulation of this pathway has been thoroughly studied. ...
Activation or inhibition of Nrf2 has been an approach to treating many diseases such as cancer and regulation of this pathway has bee …
Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product.
Zheng R, Heck DE, Mishin V, Black AT, Shakarjian MP, Kong AN, Laskin DL, Laskin JD. Zheng R, et al. Among authors: kong an. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):113-21. doi: 10.1016/j.taap.2014.01.001. Epub 2014 Jan 11. Toxicol Appl Pharmacol. 2014. PMID: 24423726 Free PMC article.
Keratinocytes contain an array of antioxidant enzymes which protect against oxidative stress. In these studies, we characterized 4-HNE-induced changes in antioxidant expression in mouse keratinocytes. ...
Keratinocytes contain an array of antioxidant enzymes which protect against oxidative stress. In these studies, we characterized 4-HN …
A semi-mechanistic integrated toxicokinetic-toxicodynamic (TK/TD) model for arsenic(III) in hepatocytes.
Stamatelos SK, Androulakis IP, Kong AN, Georgopoulos PG. Stamatelos SK, et al. Among authors: kong an. J Theor Biol. 2013 Jan 21;317:244-56. doi: 10.1016/j.jtbi.2012.09.019. Epub 2012 Oct 12. J Theor Biol. 2013. PMID: 23069314 Free PMC article.
This TK/TD framework that uses arsenic as an example can be further extended to other toxic or pharmaceutical agents....
This TK/TD framework that uses arsenic as an example can be further extended to other toxic or pharmaceutical agents....
Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal.
Huang Y, Li W, Kong AN. Huang Y, et al. Among authors: kong an. Cell Biosci. 2012 Nov 28;2(1):40. doi: 10.1186/2045-3701-2-40. Cell Biosci. 2012. PMID: 23190551 Free PMC article.
Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects.
Mandlekar S, Hong JL, Kong AN. Mandlekar S, et al. Among authors: kong an. Curr Drug Metab. 2006 Aug;7(6):661-75. doi: 10.2174/138920006778017795. Curr Drug Metab. 2006. PMID: 16918318 Review.
Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells.
Nair S, Li W, Kong AN. Nair S, et al. Among authors: kong an. Acta Pharmacol Sin. 2007 Apr;28(4):459-72. doi: 10.1111/j.1745-7254.2007.00549.x. Acta Pharmacol Sin. 2007. PMID: 17376285 Review.
This interaction between "animal-plant" ecosystems has resulted in an elaborate system of detoxification and defense mechanisms evolved by animals including humans. ...We will also discuss the kelch-like erythroid Cap'n'Collar homologue-associated protein 1 (Keap1)-Nrf2 ax …
This interaction between "animal-plant" ecosystems has resulted in an elaborate system of detoxification and defense mechanisms evolv …
Corynoline Isolated from Corydalis bungeana Turcz. Exhibits Anti-Inflammatory Effects via Modulation of Nfr2 and MAPKs.
Yang C, Zhang C, Wang Z, Tang Z, Kuang H, Kong AN. Yang C, et al. Among authors: kong an. Molecules. 2016 Jul 27;21(8):975. doi: 10.3390/molecules21080975. Molecules. 2016. PMID: 27472313 Free PMC article.
Corydalis bungeana Turcz. is an anti-inflammatory medicinal herb used widely in traditional Chinese medicine for upper respiratory tract infections. ...
Corydalis bungeana Turcz. is an anti-inflammatory medicinal herb used widely in traditional Chinese medicine for upper respiratory tr …
Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant.
Li T, Kong AN, Ma Z, Liu H, Liu P, Xiao Y, Jiang X, Wang L. Li T, et al. Among authors: kong an. Oncotarget. 2016 Apr 12;7(15):20236-48. doi: 10.18632/oncotarget.7752. Oncotarget. 2016. PMID: 26934120 Free PMC article.
PURPOSE: Pregnane x receptor (PXR) - activated overexpression of the multidrug resistance 1 (MDR1) gene is an important way for tumor cells to acquire drug resistance. ...CONCLUSIONS: PRMT1 may be an important co-activator of PXR in activating MDR1 gene during acqui …
PURPOSE: Pregnane x receptor (PXR) - activated overexpression of the multidrug resistance 1 (MDR1) gene is an important way for tumor …
Nrf2 knockout attenuates the anti-inflammatory effects of phenethyl isothiocyanate and curcumin.
Boyanapalli SS, Paredes-Gonzalez X, Fuentes F, Zhang C, Guo Y, Pung D, Saw CL, Kong AN. Boyanapalli SS, et al. Among authors: kong an. Chem Res Toxicol. 2014 Dec 15;27(12):2036-43. doi: 10.1021/tx500234h. Epub 2014 Nov 25. Chem Res Toxicol. 2014. PMID: 25387343 Free PMC article.
Nrf2(+/+) macrophages treated with PEITC and CUR exhibited a significant decrease in the expression of these anti-inflammatory genes along with an increase in the expression of hemeoxygenase-1 (HO-1), which is an antioxidative stress gene downstream of the Nrf2 tran …
Nrf2(+/+) macrophages treated with PEITC and CUR exhibited a significant decrease in the expression of these anti-inflammatory genes along w …
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