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The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.
Glas J, Konrad A, Schmechel S, Dambacher J, Seiderer J, Schroff F, Wetzke M, Roeske D, Török HP, Tonenchi L, Pfennig S, Haller D, Griga T, Klein W, Epplen JT, Folwaczny C, Lohse P, Göke B, Ochsenkühn T, Mussack T, Folwaczny M, Müller-Myhsok B, Brand S. Glas J, et al. Among authors: konrad a. Am J Gastroenterol. 2008 Mar;103(3):682-91. doi: 10.1111/j.1572-0241.2007.01694.x. Epub 2007 Dec 20. Am J Gastroenterol. 2008. PMID: 18162085
The +1059G/C polymorphism in the C-reactive protein (CRP) gene is associated with involvement of the terminal ileum and decreased serum CRP levels in patients with Crohn's disease.
Thalmaier D, Dambacher J, Seiderer J, Konrad A, Schachinger V, Pfennig S, Otte JM, Crispin A, Göke B, Ochsenkühn T, Lohse P, Brand S. Thalmaier D, et al. Among authors: konrad a. Aliment Pharmacol Ther. 2006 Oct 1;24(7):1105-15. doi: 10.1111/j.1365-2036.2006.03093.x. Aliment Pharmacol Ther. 2006. PMID: 16984505 Free article.
The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease.
Brand S, Staudinger T, Schnitzler F, Pfennig S, Hofbauer K, Dambacher J, Seiderer J, Tillack C, Konrad A, Crispin A, Göke B, Lohse P, Ochsenkühn T. Brand S, et al. Among authors: konrad a. Inflamm Bowel Dis. 2005 Jul;11(7):645-52. doi: 10.1097/01.mib.0000168372.94907.d2. Inflamm Bowel Dis. 2005. PMID: 15973118
Increased expression of the chemokine fractalkine in Crohn's disease and association of the fractalkine receptor T280M polymorphism with a fibrostenosing disease Phenotype.
Brand S, Hofbauer K, Dambacher J, Schnitzler F, Staudinger T, Pfennig S, Seiderer J, Tillack C, Konrad A, Göke B, Ochsenkühn T, Lohse P. Brand S, et al. Among authors: konrad a. Am J Gastroenterol. 2006 Jan;101(1):99-106. doi: 10.1111/j.1572-0241.2005.00361.x. Am J Gastroenterol. 2006. PMID: 16405540
Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease.
Dambacher J, Staudinger T, Seiderer J, Sisic Z, Schnitzler F, Pfennig S, Hofbauer K, Konrad A, Tillack C, Otte JM, Diebold J, Göke B, Ochsenkühn T, Lohse P, Brand S. Dambacher J, et al. Among authors: konrad a. Inflamm Bowel Dis. 2007 Jan;13(1):71-82. doi: 10.1002/ibd.20008. Inflamm Bowel Dis. 2007. PMID: 17206642
rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
Glas J, Seiderer J, Wetzke M, Konrad A, Török HP, Schmechel S, Tonenchi L, Grassl C, Dambacher J, Pfennig S, Maier K, Griga T, Klein W, Epplen JT, Schiemann U, Folwaczny C, Lohse P, Göke B, Ochsenkühn T, Müller-Myhsok B, Folwaczny M, Mussack T, Brand S. Glas J, et al. Among authors: konrad a. PLoS One. 2007 Sep 5;2(9):e819. doi: 10.1371/journal.pone.0000819. PLoS One. 2007. PMID: 17786191 Free PMC article.
Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD.
Seiderer J, Elben I, Diegelmann J, Glas J, Stallhofer J, Tillack C, Pfennig S, Jürgens M, Schmechel S, Konrad A, Göke B, Ochsenkühn T, Müller-Myhsok B, Lohse P, Brand S. Seiderer J, et al. Among authors: konrad a. Inflamm Bowel Dis. 2008 Apr;14(4):437-45. doi: 10.1002/ibd.20339. Inflamm Bowel Dis. 2008. PMID: 18088064
rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population.
Glas J, Seiderer J, Pasciuto G, Tillack C, Diegelmann J, Pfennig S, Konrad A, Schmechel S, Wetzke M, Török HP, Stallhofer J, Jürgens M, Griga T, Klein W, Epplen JT, Schiemann U, Mussack T, Lohse P, Göke B, Ochsenkühn T, Folwaczny M, Müller-Myhsok B, Brand S. Glas J, et al. Among authors: konrad a. Am J Gastroenterol. 2009 Mar;104(3):665-72. doi: 10.1038/ajg.2008.65. Epub 2009 Feb 3. Am J Gastroenterol. 2009. PMID: 19262523
244 results