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Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Cheung KL, Zhang F, Jaganathan A, Sharma R, Zhang Q, Konuma T, Shen T, Lee JY, Ren C, Chen CH, Lu G, Olson MR, Zhang W, Kaplan MH, Littman DR, Walsh MJ, Xiong H, Zeng L, Zhou MM. Cheung KL, et al. Among authors: Konuma T. Mol Cell. 2017 Mar 16;65(6):1068-1080.e5. doi: 10.1016/j.molcel.2016.12.022. Epub 2017 Mar 3. Mol Cell. 2017. PMID: 28262505 Free PMC article.
In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T helper 17 (Th17) cell differentiation. ...
In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-reg …
A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other "Shock" Drugs.
Abner E, Stoszko M, Zeng L, Chen HC, Izquierdo-Bouldstridge A, Konuma T, Zorita E, Fanunza E, Zhang Q, Mahmoudi T, Zhou MM, Filion GJ, Jordan A. Abner E, et al. Among authors: Konuma T. J Virol. 2018 Apr 27;92(10):e02056-17. doi: 10.1128/JVI.02056-17. Print 2018 May 15. J Virol. 2018. PMID: 29343578 Free PMC article.
Upon HIV-1 infection, a reservoir of latently infected resting T cells prevents the eradication of the virus from patients. To achieve complete depletion, the existing virus-suppressing antiretroviral therapy must be combined with drugs that reactivate the dormant viruses. ...
Upon HIV-1 infection, a reservoir of latently infected resting T cells prevents the eradication of the virus from patients. To achiev …
Quantitative analysis of protein-ligand interactions by NMR.
Furukawa A, Konuma T, Yanaka S, Sugase K. Furukawa A, et al. Among authors: Konuma T. Prog Nucl Magn Reson Spectrosc. 2016 Aug;96:47-57. doi: 10.1016/j.pnmrs.2016.02.002. Epub 2016 Mar 3. Prog Nucl Magn Reson Spectrosc. 2016. PMID: 27573180 Review.
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