Koo EH - Search Results

1

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.

Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. Israel MA, et al. Among authors: koo eh. Nature. 2012 Jan 25;482(7384):216-20. doi: 10.1038/nature10821. Nature. 2012. PMID: 22278060 Free PMC article.

2

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.

Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE. Lu DC, et al. Among authors: koo eh. Nat Med. 2000 Apr;6(4):397-404. doi: 10.1038/74656. Nat Med. 2000. PMID: 10742146

3

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.

Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. Weggen S, et al. Among authors: koo eh. Nature. 2001 Nov 8;414(6860):212-6. doi: 10.1038/35102591. Nature. 2001. PMID: 11700559

4

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

Koo EH, Kopan R. Koo EH, et al. Nat Med. 2004 Jul;10 Suppl:S26-33. doi: 10.1038/nm1065. Nat Med. 2004. PMID: 15272268 Review.

5

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.

Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo EH, Golde TE. Kukar T, et al. Among authors: koo eh. Nat Med. 2005 May;11(5):545-50. doi: 10.1038/nm1235. Epub 2005 Apr 17. Nat Med. 2005. PMID: 15834426

6

Substrate-targeting gamma-secretase modulators.

Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Kukar TL, et al. Among authors: koo eh. Nature. 2008 Jun 12;453(7197):925-9. doi: 10.1038/nature07055. Nature. 2008. PMID: 18548070 Free PMC article.

7

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease.

Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, Chiba AA, Tuszynski MH. Nagahara AH, et al. Among authors: koo eh. Nat Med. 2009 Mar;15(3):331-7. doi: 10.1038/nm.1912. Epub 2009 Feb 8. Nat Med. 2009. PMID: 19198615 Free PMC article.

8

Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production.

Eggert S, Midthune B, Cottrell B, Koo EH. Eggert S, et al. Among authors: koo eh. J Biol Chem. 2009 Oct 16;284(42):28943-52. doi: 10.1074/jbc.M109.038646. Epub 2009 Jul 13. J Biol Chem. 2009. PMID: 19596858 Free PMC article.

9

A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation.

Lakshmana MK, Chung JY, Wickramarachchi S, Tak E, Bianchi E, Koo EH, Kang DE. Lakshmana MK, et al. Among authors: koo eh. FASEB J. 2010 Jan;24(1):119-27. doi: 10.1096/fj.09-136457. Epub 2009 Sep 3. FASEB J. 2010. PMID: 19729516 Free PMC article.

10

Emerging therapeutics for Alzheimer's disease.

Chiang K, Koo EH. Chiang K, et al. Among authors: koo eh. Annu Rev Pharmacol Toxicol. 2014;54:381-405. doi: 10.1146/annurev-pharmtox-011613-135932. Annu Rev Pharmacol Toxicol. 2014. PMID: 24392696 Review.

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