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Targeting microbial biofilms: current and prospective therapeutic strategies.
Koo H, Allan RN, Howlin RP, Stoodley P, Hall-Stoodley L. Koo H, et al. Nat Rev Microbiol. 2017 Dec;15(12):740-755. doi: 10.1038/nrmicro.2017.99. Epub 2017 Sep 25. Nat Rev Microbiol. 2017. PMID: 28944770 Free PMC article. Review.
Candida albicans Carriage in Children with Severe Early Childhood Caries (S-ECC) and Maternal Relatedness.
Xiao J, Moon Y, Li L, Rustchenko E, Wakabayashi H, Zhao X, Feng C, Gill SR, McLaren S, Malmstrom H, Ren Y, Quivey R, Koo H, Kopycka-Kedzierawski DT. Xiao J, et al. Among authors: Koo H. PLoS One. 2016 Oct 14;11(10):e0164242. doi: 10.1371/journal.pone.0164242. eCollection 2016. PLoS One. 2016. PMID: 27741258 Free PMC article.
pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence.
Horev B, Klein MI, Hwang G, Li Y, Kim D, Koo H, Benoit DS. Horev B, et al. Among authors: Koo H. ACS Nano. 2015 Mar 24;9(3):2390-404. doi: 10.1021/nn507170s. Epub 2015 Feb 13. ACS Nano. 2015. PMID: 25661192 Free PMC article.
Farnesol release is pH-dependent with t1/2 = 7 and 15 h for release at pH 4.5 and 7.2, as nanoparticles undergo core destabilization at acidic pH, characteristic of cariogenic biofilm microenvironments. ...
Farnesol release is pH-dependent with t1/2 = 7 and 15 h for release at pH 4.5 and 7.2, as nanoparticles undergo core destabilization …
Streptococcus mutans extracellular DNA is upregulated during growth in biofilms, actively released via membrane vesicles, and influenced by components of the protein secretion machinery.
Liao S, Klein MI, Heim KP, Fan Y, Bitoun JP, Ahn SJ, Burne RA, Koo H, Brady LJ, Wen ZT. Liao S, et al. Among authors: Koo H. J Bacteriol. 2014 Jul;196(13):2355-66. doi: 10.1128/JB.01493-14. Epub 2014 Apr 18. J Bacteriol. 2014. PMID: 24748612 Free PMC article.
Compared to eDNA production of planktonic cultures, eDNA production in 5- and 24-h biofilms was increased by >3- and >1.6-fold, respectively. ...
Compared to eDNA production of planktonic cultures, eDNA production in 5- and 24-h biofilms was increased by >3- and >1.6-fold, …
Role of Clp proteins in expression of virulence properties of Streptococcus mutans.
Kajfasz JK, Martinez AR, Rivera-Ramos I, Abranches J, Koo H, Quivey RG Jr, Lemos JA. Kajfasz JK, et al. Among authors: Koo H. J Bacteriol. 2009 Apr;191(7):2060-8. doi: 10.1128/JB.01609-08. Epub 2009 Jan 30. J Bacteriol. 2009. PMID: 19181818 Free PMC article.
Influence of apigenin on gtf gene expression in Streptococcus mutans UA159.
Koo H, Seils J, Abranches J, Burne RA, Bowen WH, Quivey RG Jr. Koo H, et al. Antimicrob Agents Chemother. 2006 Feb;50(2):542-6. doi: 10.1128/AAC.50.2.542-546.2006. Antimicrob Agents Chemother. 2006. PMID: 16436708 Free PMC article.
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