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GPCR activation mechanisms across classes and macro/microscales.
Hauser AS, Kooistra AJ, Munk C, Heydenreich FM, Veprintsev DB, Bouvier M, Babu MM, Gloriam DE. Hauser AS, et al. Among authors: kooistra aj. Nat Struct Mol Biol. 2021 Nov;28(11):879-888. doi: 10.1038/s41594-021-00674-7. Epub 2021 Nov 10. Nat Struct Mol Biol. 2021. PMID: 34759375 Free PMC article.
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Šenel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D. Zhang X, et al. Among authors: kooistra aj. Mol Cell. 2020 Nov 5;80(3):485-500.e7. doi: 10.1016/j.molcel.2020.09.020. Epub 2020 Oct 6. Mol Cell. 2020. PMID: 33027691 Free article.
Structure of the class D GPCR Ste2 dimer coupled to two G proteins.
Velazhahan V, Ma N, Pándy-Szekeres G, Kooistra AJ, Lee Y, Gloriam DE, Vaidehi N, Tate CG. Velazhahan V, et al. Among authors: kooistra aj. Nature. 2021 Jan;589(7840):148-153. doi: 10.1038/s41586-020-2994-1. Epub 2020 Dec 2. Nature. 2021. PMID: 33268889 Free PMC article.
GPCRdb in 2021: integrating GPCR sequence, structure and function.
Kooistra AJ, Mordalski S, Pándy-Szekeres G, Esguerra M, Mamyrbekov A, Munk C, Keserű GM, Gloriam DE. Kooistra AJ, et al. Nucleic Acids Res. 2021 Jan 8;49(D1):D335-D343. doi: 10.1093/nar/gkaa1080. Nucleic Acids Res. 2021. PMID: 33270898 Free PMC article.
The G protein database, GproteinDb.
Pándy-Szekeres G, Esguerra M, Hauser AS, Caroli J, Munk C, Pilger S, Keserű GM, Kooistra AJ, Gloriam DE. Pándy-Szekeres G, et al. Among authors: kooistra aj. Nucleic Acids Res. 2022 Jan 7;50(D1):D518-D525. doi: 10.1093/nar/gkab852. Nucleic Acids Res. 2022. PMID: 34570219 Free PMC article.
An online GPCR structure analysis platform.
Kooistra AJ, Munk C, Hauser AS, Gloriam DE. Kooistra AJ, et al. Nat Struct Mol Biol. 2021 Nov;28(11):875-878. doi: 10.1038/s41594-021-00675-6. Epub 2021 Nov 10. Nat Struct Mol Biol. 2021. PMID: 34759374
A community Biased Signaling Atlas.
Caroli J, Mamyrbekov A, Harpsøe K, Gardizi S, Dörries L, Ghosh E, Hauser AS, Kooistra AJ, Gloriam DE. Caroli J, et al. Among authors: kooistra aj. Nat Chem Biol. 2023 May;19(5):531-535. doi: 10.1038/s41589-023-01292-8. Nat Chem Biol. 2023. PMID: 36973443 No abstract available.
51 results