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Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways.
Schimmel J, Muñoz-Subirana N, Kool H, van Schendel R, van der Vlies S, Kamp JA, de Vrij FMS, Kushner SA, Smith GCM, Boulton SJ, Tijsterman M. Schimmel J, et al. Among authors: kool h. Cell Rep. 2023 Feb 28;42(2):112019. doi: 10.1016/j.celrep.2023.112019. Epub 2023 Jan 25. Cell Rep. 2023. PMID: 36701230 Free article.
Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation.
Sampadi B, Vermeulen S, Mišovic B, Boei JJ, Batth TS, Chang JG, Paulsen MT, Magnuson B, Schimmel J, Kool H, Olie CS, Everts B, Vertegaal ACO, Olsen JV, Ljungman M, Jeggo PA, Mullenders LHF, Vrieling H. Sampadi B, et al. Among authors: kool h. Cells. 2022 Nov 27;11(23):3794. doi: 10.3390/cells11233794. Cells. 2022. PMID: 36497055 Free PMC article.
Inhibition of retinoic acid signaling induces aberrant pericyte coverage and differentiation resulting in vascular defects in congenital diaphragmatic hernia.
Kool HM, Bürgisser PE, Edel GG, de Kleer I, Boerema-de Munck A, de Laat I, Chrifi I, Cheng C, van Cappellen WA, Kremers GJ, Tibboel D, Rottier RJ. Kool HM, et al. Am J Physiol Lung Cell Mol Physiol. 2019 Sep 1;317(3):L317-L331. doi: 10.1152/ajplung.00104.2018. Epub 2019 Jul 3. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 31268349 Free article.
Treatment of rat congenital diaphragmatic hernia with sildenafil and NS-304, selexipag's active compound, at the pseudoglandular stage improves lung vasculature.
Mous DS, Kool HM, Burgisser PE, Buscop-van Kempen MJ, Nagata K, Boerema-de Munck A, van Rosmalen J, Dzyubachyk O, Wijnen RMH, Tibboel D, Rottier RJ. Mous DS, et al. Among authors: kool hm. Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L276-L285. doi: 10.1152/ajplung.00392.2017. Epub 2018 May 10. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 29745254 Free article.
Pulmonary vascular development in congenital diaphragmatic hernia.
Mous DS, Kool HM, Wijnen R, Tibboel D, Rottier RJ. Mous DS, et al. Among authors: kool hm. Eur Respir Rev. 2018 Jan 24;27(147):170104. doi: 10.1183/16000617.0104-2017. Print 2018 Mar 31. Eur Respir Rev. 2018. PMID: 29367409 Free PMC article. Review.
41 results