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Daunomycin- and adriamycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugates; toxicity reduction by improved drug-delivery.
Seymour LW, Duncan R, Kopecková P, Kopecek J. Seymour LW, et al. Cancer Treat Rev. 1987 Dec;14(3-4):319-27. doi: 10.1016/0305-7372(87)90024-7. Cancer Treat Rev. 1987. PMID: 3326668 Review. No abstract available.
Combination chemotherapy and photodynamic therapy with N-(2-hydroxypropyl) methacrylamide copolymer-bound anticancer drugs inhibit human ovarian carcinoma heterotransplanted in nude mice.
Peterson CM, Lu JM, Sun Y, Peterson CA, Shiah JG, Straight RC, Kopecek J. Peterson CM, et al. Cancer Res. 1996 Sep 1;56(17):3980-5. Cancer Res. 1996. PMID: 8752167
Tumor-bearing mice were allocated to the following protocols: (a) Adriamycin at 1 mg/kg, P-A at 30 mg/kg (2.2 mg/kg Adriamycin equivalent), and controls (n = 6 each); (b) Mce6 and light (2 h after administration: 650 nm light for 15 min to deliver 220 J/cm2) at 1.25, 2.5, …
Tumor-bearing mice were allocated to the following protocols: (a) Adriamycin at 1 mg/kg, P-A at 30 mg/kg (2.2 mg/kg Adriamycin equivalent), …
Biodistribution and antitumour efficacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice.
Shiah JG, Dvorák M, Kopecková P, Sun Y, Peterson CM, Kopecek J. Shiah JG, et al. Eur J Cancer. 2001 Jan;37(1):131-9. doi: 10.1016/s0959-8049(00)00374-9. Eur J Cancer. 2001. PMID: 11165140
Evaluation of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of transferrin and anti-transferrin receptor antibody conjugates.
Flanagan PA, Kopecková P, Kopecek J, Duncan R. Flanagan PA, et al. Biochim Biophys Acta. 1989 Oct 13;993(1):83-91. doi: 10.1016/0304-4165(89)90146-3. Biochim Biophys Acta. 1989. PMID: 2804126
Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro.
Duncan R, Kopecková-Rejmanová P, Strohalm J, Hume I, Cable HC, Pohl J, Lloyd JB, Kopecek J. Duncan R, et al. Br J Cancer. 1987 Feb;55(2):165-74. doi: 10.1038/bjc.1987.33. Br J Cancer. 1987. PMID: 3468994 Free PMC article.
Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.
Seymour LW, Duncan R, Strohalm J, Kopecek J. Seymour LW, et al. J Biomed Mater Res. 1987 Nov;21(11):1341-58. doi: 10.1002/jbm.820211106. J Biomed Mater Res. 1987. PMID: 3680316
Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro.
Rihova B, Bilej M, Vetvicka V, Ulbrich K, Strohalm J, Kopecek J, Duncan R. Rihova B, et al. Biomaterials. 1989 Jul;10(5):335-42. doi: 10.1016/0142-9612(89)90075-6. Biomaterials. 1989. PMID: 2765631
Effect of galactose on interaction of N-(2-hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: preliminary application to an anticancer agent, daunomycin.
O'Hare KB, Hume IC, Scarlett L, Chytrý V, Kopecková P, Kopecek J, Duncan R. O'Hare KB, et al. Hepatology. 1989 Aug;10(2):207-14. doi: 10.1002/hep.1840100215. Hepatology. 1989. PMID: 2545589
The pharmacokinetics of polymer-bound adriamycin.
Seymour LW, Ulbrich K, Strohalm J, Kopecek J, Duncan R. Seymour LW, et al. Biochem Pharmacol. 1990 Mar 15;39(6):1125-31. doi: 10.1016/0006-2952(90)90293-t. Biochem Pharmacol. 1990. PMID: 2322298
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