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Daunomycin- and adriamycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugates; toxicity reduction by improved drug-delivery.
Seymour LW, Duncan R, Kopecková P, Kopecek J. Seymour LW, et al. Cancer Treat Rev. 1987 Dec;14(3-4):319-27. doi: 10.1016/0305-7372(87)90024-7. Cancer Treat Rev. 1987. PMID: 3326668 Review. No abstract available.
Biodistribution and antitumour efficacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice.
Shiah JG, Dvorák M, Kopecková P, Sun Y, Peterson CM, Kopecek J. Shiah JG, et al. Eur J Cancer. 2001 Jan;37(1):131-9. doi: 10.1016/s0959-8049(00)00374-9. Eur J Cancer. 2001. PMID: 11165140
Treatment with P-DOX (mol. wt > or = 160 kDa) inhibited tumour growth more efficiently than that of 22 kDa P-DOX or free DOX (P<0.02) at a 2.2 mg/kg DOX equivalent dose. In conclusion, the administration of long circulating P-DOX resulted in enha …
Treatment with P-DOX (mol. wt > or = 160 kDa) inhibited tumour growth more efficiently than that of 22 kDa P-DOX or free DO …
Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia.
Duncan R, Kopecková P, Strohalm J, Hume IC, Lloyd JB, Kopecek J. Duncan R, et al. Br J Cancer. 1988 Feb;57(2):147-56. doi: 10.1038/bjc.1988.31. Br J Cancer. 1988. PMID: 3358905 Free PMC article.
DBA2 mice were inoculated i.p. with 10(5)L1210 cells. Animals subsequently treated with daunomycin (single i.p. dose, 0.25-5.0 mg kg-1) all died. ...Radioiodination of polymer showed approximately 75% of polymer-drug conjugate to be excreted 24 h after i.p. a …
DBA2 mice were inoculated i.p. with 10(5)L1210 cells. Animals subsequently treated with daunomycin (single i.p. dose, 0.25-5.0 …
Evaluation of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of transferrin and anti-transferrin receptor antibody conjugates.
Flanagan PA, Kopecková P, Kopecek J, Duncan R. Flanagan PA, et al. Biochim Biophys Acta. 1989 Oct 13;993(1):83-91. doi: 10.1016/0304-4165(89)90146-3. Biochim Biophys Acta. 1989. PMID: 2804126
Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous administration in the rat.
Wedge SR, Duncan R, Kopeckova P. Wedge SR, et al. Br J Cancer. 1991 Apr;63(4):546-9. doi: 10.1038/bjc.1991.128. Br J Cancer. 1991. PMID: 1827030 Free PMC article. No abstract available.
Effect of galactose on interaction of N-(2-hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: preliminary application to an anticancer agent, daunomycin.
O'Hare KB, Hume IC, Scarlett L, Chytrý V, Kopecková P, Kopecek J, Duncan R. O'Hare KB, et al. Hepatology. 1989 Aug;10(2):207-14. doi: 10.1002/hep.1840100215. Hepatology. 1989. PMID: 2545589
Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma.
Minko T, Kopecková P, Kopecek J. Minko T, et al. Int J Cancer. 2000 Apr 1;86(1):108-17. doi: 10.1002/(sici)1097-0215(20000401)86:1<108::aid-ijc17>3.0.co;2-8. Int J Cancer. 2000. PMID: 10728603
An enhanced accumulation of P(GFLG)-DOX in the tumor was observed, whereas only low concentrations of DOX were detected in other organs following P(GFLG)-DOX administration. ...P(GFLG)-DOX also produced tumor tissue hypoxia and significantly activated lipid p …
An enhanced accumulation of P(GFLG)-DOX in the tumor was observed, whereas only low concentrations of DOX were detected in other orga …
Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells.
Nishiyama N, Nori A, Malugin A, Kasuya Y, Kopecková P, Kopecek J. Nishiyama N, et al. Cancer Res. 2003 Nov 15;63(22):7876-82. Cancer Res. 2003. PMID: 14633716
All treatments resulted in similar gene expression profiles up to 12 h (e.g., down-regulation of CDK4 and up-regulation of APAF-1), although P(AP-GA)-treated cells showed delayed gene expression because of time-dependent internalization of the conjugate and intracellular d …
All treatments resulted in similar gene expression profiles up to 12 h (e.g., down-regulation of CDK4 and up-regulation of APAF-1), although …
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