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Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.
McLeod RL, Tulshian DB, Bolser DC, Varty GB, Baptista M, Fernandez X, Parra LE, Zimmer JC, Erickson CH, Ho GD, Jia Y, Ng FW, Korfmacher W, Xu X, Veals J, Smith-Torhan A, Wainhaus S, Fawzi AB, Austin TM, van Heek M, Hey JA. McLeod RL, et al. Among authors: korfmacher w. Eur J Pharmacol. 2010 Mar 25;630(1-3):112-20. doi: 10.1016/j.ejphar.2009.12.003. Epub 2009 Dec 16. Eur J Pharmacol. 2010. PMID: 20006596 Free PMC article.
Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687).
McLeod RL, Rizzo CA, West RE Jr, Aslanian R, McCormick K, Bryant M, Hsieh Y, Korfmacher W, Mingo GG, Varty L, Williams SM, Shih NY, Egan RW, Hey JA. McLeod RL, et al. Among authors: korfmacher w. J Pharmacol Exp Ther. 2003 Jun;305(3):1037-44. doi: 10.1124/jpet.103.049254. Epub 2003 Mar 20. J Pharmacol Exp Ther. 2003. PMID: 12649305
The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.
Ho GD, Anthes J, Bercovici A, Caldwell JP, Cheng KC, Cui X, Fawzi A, Fernandez X, Greenlee WJ, Hey J, Korfmacher W, Lu SX, McLeod RL, Ng F, Torhan AS, Tan Z, Tulshian D, Varty GB, Xu X, Zhang H. Ho GD, et al. Among authors: korfmacher w. Bioorg Med Chem Lett. 2009 May 1;19(9):2519-23. doi: 10.1016/j.bmcl.2009.03.031. Epub 2009 Mar 14. Bioorg Med Chem Lett. 2009. PMID: 19339177
Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A).
Corboz MR, Rivelli MA, McCormick KD, Wan Y, Shah H, Umland S, Lieber G, Jia Y, McLeod RL, Morgan C, Varty GB, Wu J, Feng KI, Boyce CW, Aslanian RG, Palamanda J, Nomeir AA, Korfmacher W, Hunter JC, Anthes JC, Hey JA. Corboz MR, et al. Among authors: korfmacher w. J Pharmacol Exp Ther. 2011 Apr;337(1):256-66. doi: 10.1124/jpet.110.175794. Epub 2011 Jan 13. J Pharmacol Exp Ther. 2011. PMID: 21233198
Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery.
Korfmacher WA, Cox KA, Ng KJ, Veals J, Hsieh Y, Wainhaus S, Broske L, Prelusky D, Nomeir A, White RE. Korfmacher WA, et al. Rapid Commun Mass Spectrom. 2001;15(5):335-40. doi: 10.1002/rcm.235. Rapid Commun Mass Spectrom. 2001. PMID: 11241763
114 results