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XIAP: apoptotic brake and promising therapeutic target.
Holcik M, Gibson H, Korneluk RG. Holcik M, et al. Among authors: korneluk rg. Apoptosis. 2001 Aug;6(4):253-61. doi: 10.1023/a:1011379307472. Apoptosis. 2001. PMID: 11445667 Review.
Distinct patterns of expression of the inhibitor of apoptosis protein cIAP2 during murine embryogenesis.
Shafey D, Korneluk R, Holcik M. Shafey D, et al. Apoptosis. 2006 Jul;11(7):1257-9. doi: 10.1007/s10495-006-6985-y. Apoptosis. 2006. PMID: 16699955 No abstract available.
Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma.
Wagenknecht B, Glaser T, Naumann U, Kügler S, Isenmann S, Bähr M, Korneluk R, Liston P, Weller M. Wagenknecht B, et al. Cell Death Differ. 1999 Apr;6(4):370-6. doi: 10.1038/sj.cdd.4400503. Cell Death Differ. 1999. PMID: 10381630
Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition.
Goping IS, Barry M, Liston P, Sawchuk T, Constantinescu G, Michalak KM, Shostak I, Roberts DL, Hunter AM, Korneluk R, Bleackley RC. Goping IS, et al. Immunity. 2003 Mar;18(3):355-65. doi: 10.1016/s1074-7613(03)00032-3. Immunity. 2003. PMID: 12648453
Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization.
Morón-Calvente V, Romero-Pinedo S, Toribio-Castelló S, Plaza-Díaz J, Abadía-Molina AC, Rojas-Barros DI, Beug ST, LaCasse EC, MacKenzie A, Korneluk R, Abadía-Molina F. Morón-Calvente V, et al. PLoS One. 2018 Mar 8;13(3):e0193643. doi: 10.1371/journal.pone.0193643. eCollection 2018. PLoS One. 2018. PMID: 29518103 Free PMC article.
Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex.
Arora V, Cheung HH, Plenchette S, Micali OC, Liston P, Korneluk RG. Arora V, et al. Among authors: korneluk rg. J Biol Chem. 2007 Sep 7;282(36):26202-9. doi: 10.1074/jbc.M700776200. Epub 2007 Jul 5. J Biol Chem. 2007. PMID: 17613533
Smac mimetic compounds potentiate interleukin-1beta-mediated cell death.
Cheung HH, Beug ST, St Jean M, Brewster A, Kelly NL, Wang S, Korneluk RG. Cheung HH, et al. Among authors: korneluk rg. J Biol Chem. 2010 Dec 24;285(52):40612-23. doi: 10.1074/jbc.M110.183616. Epub 2010 Oct 18. J Biol Chem. 2010. PMID: 20956527 Free PMC article.
Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma.
Beug ST, Beauregard CE, Healy C, Sanda T, St-Jean M, Chabot J, Walker DE, Mohan A, Earl N, Lun X, Senger DL, Robbins SM, Staeheli P, Forsyth PA, Alain T, LaCasse EC, Korneluk RG. Beug ST, et al. Among authors: korneluk rg. Nat Commun. 2017 Feb 15;8:14278. doi: 10.1038/ncomms14278. Nat Commun. 2017. PMID: 28198370 Free PMC article.
Modulation of immune signalling by inhibitors of apoptosis.
Beug ST, Cheung HH, LaCasse EC, Korneluk RG. Beug ST, et al. Among authors: korneluk rg. Trends Immunol. 2012 Nov;33(11):535-45. doi: 10.1016/j.it.2012.06.004. Epub 2012 Jul 24. Trends Immunol. 2012. PMID: 22836014 Review.
XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes.
Emamaullee JA, Rajotte RV, Liston P, Korneluk RG, Lakey JR, Shapiro AM, Elliott JF. Emamaullee JA, et al. Among authors: korneluk rg. Diabetes. 2005 Sep;54(9):2541-8. doi: 10.2337/diabetes.54.9.2541. Diabetes. 2005. PMID: 16123341
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