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Automated planar electrode electrophysiology in drug discovery: examples of the use of QPatch in basic characterization and high content screening on Na(v), K(Ca)2.3, and K(v)11.1 channels.
Korsgaard MP, Strøbaek D, Christophersen P. Korsgaard MP, et al. Comb Chem High Throughput Screen. 2009 Jan;12(1):51-63. doi: 10.2174/138620709787048037. Comb Chem High Throughput Screen. 2009. PMID: 19149491 Review.
NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.
Nausch B, Rode F, Jørgensen S, Nardi A, Korsgaard MP, Hougaard C, Bonev AD, Brown WD, Dyhring T, Strøbæk D, Olesen SP, Christophersen P, Grunnet M, Nelson MT, Rønn LC. Nausch B, et al. Among authors: korsgaard mp. J Pharmacol Exp Ther. 2014 Sep;350(3):520-30. doi: 10.1124/jpet.113.212662. Epub 2014 Jun 20. J Pharmacol Exp Ther. 2014. PMID: 24951278 Free PMC article.
K(v)7 channels: function, pharmacology and channel modulators.
Dalby-Brown W, Hansen HH, Korsgaard MP, Mirza N, Olesen SP. Dalby-Brown W, et al. Among authors: korsgaard mp. Curr Top Med Chem. 2006;6(10):999-1023. doi: 10.2174/156802606777323728. Curr Top Med Chem. 2006. PMID: 16787276 Review.
High throughput electrophysiology: new perspectives for ion channel drug discovery.
Willumsen NJ, Bech M, Olesen SP, Jensen BS, Korsgaard MP, Christophersen P. Willumsen NJ, et al. Among authors: korsgaard mp. Receptors Channels. 2003;9(1):3-12. Receptors Channels. 2003. PMID: 12825293 Review.
Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery.
Asmild M, Oswald N, Krzywkowski KM, Friis S, Jacobsen RB, Reuter D, Taboryski R, Kutchinsky J, Vestergaard RK, Schrøder RL, Sørensen CB, Bech M, Korsgaard MP, Willumsen NJ. Asmild M, et al. Among authors: korsgaard mp. Receptors Channels. 2003;9(1):49-58. Receptors Channels. 2003. PMID: 12825298
Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro.
Fanoe S, Jensen GB, Sjøgren P, Korsgaard MP, Grunnet M. Fanoe S, et al. Among authors: korsgaard mp. Br J Clin Pharmacol. 2009 Feb;67(2):172-9. doi: 10.1111/j.1365-2125.2008.03327.x. Epub 2008 Oct 15. Br J Clin Pharmacol. 2009. PMID: 19159406 Free PMC article.
High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template.
Harrison T, Korsgaard MP, Swain CJ, Cascieri MA, Sadowski S, Seabrook GR. Harrison T, et al. Among authors: korsgaard mp. Bioorg Med Chem Lett. 1998 Jun 2;8(11):1343-8. doi: 10.1016/s0960-894x(98)00215-7. Bioorg Med Chem Lett. 1998. PMID: 9871763