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Bax suppresses tumorigenesis and stimulates apoptosis in vivo.
Yin C, Knudson CM, Korsmeyer SJ, Van Dyke T. Yin C, et al. Among authors: korsmeyer sj. Nature. 1997 Feb 13;385(6617):637-40. doi: 10.1038/385637a0. Nature. 1997. PMID: 9024662
Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.
Chavez-Reyes A, Parant JM, Amelse LL, de Oca Luna RM, Korsmeyer SJ, Lozano G. Chavez-Reyes A, et al. Among authors: korsmeyer sj. Cancer Res. 2003 Dec 15;63(24):8664-9. Cancer Res. 2003. PMID: 14695178
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis.
He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, An Z, Loh J, Fisher J, Sun Q, Korsmeyer S, Packer M, May HI, Hill JA, Virgin HW, Gilpin C, Xiao G, Bassel-Duby R, Scherer PE, Levine B. He C, et al. Among authors: korsmeyer s. Nature. 2012 Jan 18;481(7382):511-5. doi: 10.1038/nature10758. Nature. 2012. PMID: 22258505 Free PMC article.
BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity.
Ross AJ, Amy SP, Mahar PL, Lindsten T, Knudson CM, Thompson CB, Korsmeyer SJ, MacGregor GR. Ross AJ, et al. Among authors: korsmeyer sj. Dev Biol. 2001 Nov 15;239(2):295-308. doi: 10.1006/dbio.2001.0445. Dev Biol. 2001. PMID: 11784036
The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2.
Ojala PM, Yamamoto K, Castaños-Vélez E, Biberfeld P, Korsmeyer SJ, Mäkelä TP. Ojala PM, et al. Among authors: korsmeyer sj. Nat Cell Biol. 2000 Nov;2(11):819-25. doi: 10.1038/35041064. Nat Cell Biol. 2000. PMID: 11056537
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.
Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, Korsmeyer SJ. Cheng EH, et al. Among authors: korsmeyer sj. Mol Cell. 2001 Sep;8(3):705-11. doi: 10.1016/s1097-2765(01)00320-3. Mol Cell. 2001. PMID: 11583631
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.
Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH. Korsmeyer SJ, et al. Cell Death Differ. 2000 Dec;7(12):1166-73. doi: 10.1038/sj.cdd.4400783. Cell Death Differ. 2000. PMID: 11175253 Review.
The ability of Bcl-x(L) and Bcl-2 to prevent apoptosis can be differentially regulated.
Gottschalk AR, Boise LH, Oltvai ZN, Accavitti MA, Korsmeyer SJ, Quintáns J, Thompson CB. Gottschalk AR, et al. Among authors: korsmeyer sj. Cell Death Differ. 1996 Jan;3(1):113-8. Cell Death Differ. 1996. PMID: 17180062
Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.
Chong MJ, Murray MR, Gosink EC, Russell HR, Srinivasan A, Kapsetaki M, Korsmeyer SJ, McKinnon PJ. Chong MJ, et al. Among authors: korsmeyer sj. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):889-94. doi: 10.1073/pnas.97.2.889. Proc Natl Acad Sci U S A. 2000. PMID: 10639175 Free PMC article.
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
Lindsten T, Ross AJ, King A, Zong WX, Rathmell JC, Shiels HA, Ulrich E, Waymire KG, Mahar P, Frauwirth K, Chen Y, Wei M, Eng VM, Adelman DM, Simon MC, Ma A, Golden JA, Evan G, Korsmeyer SJ, MacGregor GR, Thompson CB. Lindsten T, et al. Among authors: korsmeyer sj. Mol Cell. 2000 Dec;6(6):1389-99. doi: 10.1016/s1097-2765(00)00136-2. Mol Cell. 2000. PMID: 11163212 Free PMC article.
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