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Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors.
Lovering F, Morgan P, Allais C, Aulabaugh A, Brodfuehrer J, Chang J, Coe J, Ding W, Dowty H, Fleming M, Frisbie R, Guzova J, Hepworth D, Jasti J, Kortum S, Kurumbail R, Mohan S, Papaioannou N, Strohbach JW, Vincent F, Lee K, Zapf CW. Lovering F, et al. Among authors: kortum s. Eur J Med Chem. 2018 Feb 10;145:606-621. doi: 10.1016/j.ejmech.2017.12.041. Epub 2017 Dec 15. Eur J Med Chem. 2018. PMID: 29348070
Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells.
Li J, Wang B, Juba BM, Vazquez M, Kortum SW, Pierce BS, Pacheco M, Roberts L, Strohbach JW, Jones LH, Hett E, Thorarensen A, Telliez JB, Sharei A, Bunnage M, Gilbert JB. Li J, et al. Among authors: kortum sw. ACS Chem Biol. 2017 Dec 15;12(12):2970-2974. doi: 10.1021/acschembio.7b00683. Epub 2017 Nov 13. ACS Chem Biol. 2017. PMID: 29088528
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
Jones P, Storer RI, Sabnis YA, Wakenhut FM, Whitlock GA, England KS, Mukaiyama T, Dehnhardt CM, Coe JW, Kortum SW, Chrencik JE, Brown DG, Jones RM, Murphy JR, Yeoh T, Morgan P, Kilty I. Jones P, et al. Among authors: kortum sw. J Med Chem. 2017 Jan 26;60(2):767-786. doi: 10.1021/acs.jmedchem.6b01634. Epub 2017 Jan 4. J Med Chem. 2017. PMID: 27983835
Thienopyrimidine-based P2Y12 platelet aggregation inhibitors.
Kortum SW, Lachance RM, Schweitzer BA, Yalamanchili G, Rahman H, Ennis MD, Huff RM, TenBrink RE. Kortum SW, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5919-23. doi: 10.1016/j.bmcl.2009.08.059. Epub 2009 Aug 20. Bioorg Med Chem Lett. 2009. PMID: 19748783
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1.
Kortum SW, Benson TE, Bienkowski MJ, Emmons TL, Prince DB, Paddock DJ, Tomasselli AG, Moon JB, LaBorde A, TenBrink RE. Kortum SW, et al. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3378-83. doi: 10.1016/j.bmcl.2007.03.096. Epub 2007 Apr 3. Bioorg Med Chem Lett. 2007. PMID: 17434734
[Optimized management of polytraumatized patients by prehospital ultrasound].
Walcher F, Kortüm S, Kirschning T, Weihgold N, Marzi I. Walcher F, et al. Among authors: kortum s. Unfallchirurg. 2002 Nov;105(11):986-94. doi: 10.1007/s00113-002-0517-1. Unfallchirurg. 2002. PMID: 12402124 German.
Environmental change and hedonic cost functions for automobiles.
Berry S, Kortum S, Pakes A. Berry S, et al. Among authors: kortum s. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12731-8. doi: 10.1073/pnas.93.23.12731. Proc Natl Acad Sci U S A. 1996. PMID: 8917486 Free PMC article.