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Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.
Yu H, Kortylewski M, Pardoll D. Yu H, et al. Among authors: kortylewski m. Nat Rev Immunol. 2007 Jan;7(1):41-51. doi: 10.1038/nri1995. Nat Rev Immunol. 2007. PMID: 17186030 Review.
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells.
Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, Bhattacharya R, Gabrilovich D, Heller R, Coppola D, Dalton W, Jove R, Pardoll D, Yu H. Wang T, et al. Among authors: kortylewski m. Nat Med. 2004 Jan;10(1):48-54. doi: 10.1038/nm976. Epub 2003 Dec 21. Nat Med. 2004. PMID: 14702634
Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects.
Burdelya L, Kujawski M, Niu G, Zhong B, Wang T, Zhang S, Kortylewski M, Shain K, Kay H, Djeu J, Dalton W, Pardoll D, Wei S, Yu H. Burdelya L, et al. Among authors: kortylewski m. J Immunol. 2005 Apr 1;174(7):3925-31. doi: 10.4049/jimmunol.174.7.3925. J Immunol. 2005. PMID: 15778348 Free PMC article.
Targeting STAT3 affects melanoma on multiple fronts.
Kortylewski M, Jove R, Yu H. Kortylewski M, et al. Cancer Metastasis Rev. 2005 Jun;24(2):315-27. doi: 10.1007/s10555-005-1580-1. Cancer Metastasis Rev. 2005. PMID: 15986140 Review.
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways.
Xu Q, Briggs J, Park S, Niu G, Kortylewski M, Zhang S, Gritsko T, Turkson J, Kay H, Semenza GL, Cheng JQ, Jove R, Yu H. Xu Q, et al. Among authors: kortylewski m. Oncogene. 2005 Aug 25;24(36):5552-60. doi: 10.1038/sj.onc.1208719. Oncogene. 2005. PMID: 16007214
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity.
Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, Niu G, Kay H, Mulé J, Kerr WG, Jove R, Pardoll D, Yu H. Kortylewski M, et al. Nat Med. 2005 Dec;11(12):1314-21. doi: 10.1038/nm1325. Epub 2005 Nov 20. Nat Med. 2005. PMID: 16288283
Stat3 as a potential target for cancer immunotherapy.
Kortylewski M, Yu H. Kortylewski M, et al. J Immunother. 2007 Feb-Mar;30(2):131-9. doi: 10.1097/01.cji.0000211327.76266.65. J Immunother. 2007. PMID: 17471161 Review.
Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity.
Harris TJ, Grosso JF, Yen HR, Xin H, Kortylewski M, Albesiano E, Hipkiss EL, Getnet D, Goldberg MV, Maris CH, Housseau F, Yu H, Pardoll DM, Drake CG. Harris TJ, et al. Among authors: kortylewski m. J Immunol. 2007 Oct 1;179(7):4313-7. doi: 10.4049/jimmunol.179.7.4313. J Immunol. 2007. PMID: 17878325
Role of Stat3 in suppressing anti-tumor immunity.
Kortylewski M, Yu H. Kortylewski M, et al. Curr Opin Immunol. 2008 Apr;20(2):228-33. doi: 10.1016/j.coi.2008.03.010. Epub 2008 May 12. Curr Opin Immunol. 2008. PMID: 18479894 Free PMC article. Review.
Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells.
Niu G, Briggs J, Deng J, Ma Y, Lee H, Kortylewski M, Kujawski M, Kay H, Cress WD, Jove R, Yu H. Niu G, et al. Among authors: kortylewski m. Mol Cancer Res. 2008 Jul;6(7):1099-105. doi: 10.1158/1541-7786.MCR-07-2177. Mol Cancer Res. 2008. PMID: 18644974 Free PMC article.
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