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583 results
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Philosophy of science. The Cha-Cha-Cha Theory of Scientific Discovery.
Koshland DE Jr. Koshland DE Jr. Science. 2007 Aug 10;317(5839):761-2. doi: 10.1126/science.1147166. Science. 2007. PMID: 17690282 No abstract available.
Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates.
Radisky ES, Lee JM, Lu CJ, Koshland DE Jr. Radisky ES, et al. Among authors: koshland de jr. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6835-40. doi: 10.1073/pnas.0601910103. Epub 2006 Apr 24. Proc Natl Acad Sci U S A. 2006. PMID: 16636277 Free PMC article.
Role of the intramolecular hydrogen bond network in the inhibitory power of chymotrypsin inhibitor 2.
Radisky ES, Lu CJ, Kwan G, Koshland DE Jr. Radisky ES, et al. Among authors: koshland de jr. Biochemistry. 2005 May 10;44(18):6823-30. doi: 10.1021/bi047301w. Biochemistry. 2005. PMID: 15865427
Crazy, but correct.
Koshland DE Jr. Koshland DE Jr. Nature. 2004 Nov 25;432(7016):447. doi: 10.1038/432447a. Nature. 2004. PMID: 15565132 No abstract available.
Binding, proteolytic, and crystallographic analyses of mutations at the protease-inhibitor interface of the subtilisin BPN'/chymotrypsin inhibitor 2 complex.
Radisky ES, Kwan G, Karen Lu CJ, Koshland DE Jr. Radisky ES, et al. Among authors: koshland de jr. Biochemistry. 2004 Nov 2;43(43):13648-56. doi: 10.1021/bi048797k. Biochemistry. 2004. PMID: 15504027
The role of the protein core in the inhibitory power of the classic serine protease inhibitor, chymotrypsin inhibitor 2.
Radisky ES, King DS, Kwan G, Koshland DE Jr. Radisky ES, et al. Among authors: koshland de jr. Biochemistry. 2003 Jun 3;42(21):6484-92. doi: 10.1021/bi034275d. Biochemistry. 2003. PMID: 12767231
Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.
Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE Jr. Yu EW, et al. Among authors: koshland de jr. Science. 2003 May 9;300(5621):976-80. doi: 10.1126/science.1083137. Science. 2003. PMID: 12738864 Free article.
Proteomics and models for enzyme cooperativity.
Koshland DE Jr, Hamadani K. Koshland DE Jr, et al. J Biol Chem. 2002 Dec 6;277(49):46841-4. doi: 10.1074/jbc.R200014200. Epub 2002 Aug 19. J Biol Chem. 2002. PMID: 12189158 Free article. Review. No abstract available.
A clogged gutter mechanism for protease inhibitors.
Radisky ES, Koshland DE Jr. Radisky ES, et al. Among authors: koshland de jr. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10316-21. doi: 10.1073/pnas.112332899. Epub 2002 Jul 25. Proc Natl Acad Sci U S A. 2002. PMID: 12142461 Free PMC article.
Special essay. The seven pillars of life.
Koshland DE Jr. Koshland DE Jr. Science. 2002 Mar 22;295(5563):2215-6. doi: 10.1126/science.1068489. Science. 2002. PMID: 11910092 Free article. No abstract available.
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