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Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft.
Bioorg Med Chem Lett. 2016 Jul 15;26(14):3232-3236. doi: 10.1016/j.bmcl.2016.05.065. Epub 2016 May 24.
Bioorg Med Chem Lett. 2016.
PMID: 27262595
Free PMC article.
Secondary Interaction Interfaces with PCNA Control Conformational Switching of DNA Polymerase PolB from Polymerization to Editing.
Xu X, Yan C, Kossmann BR, Ivanov I.
Xu X, et al. Among authors: kossmann br.
J Phys Chem B. 2016 Aug 25;120(33):8379-88. doi: 10.1021/acs.jpcb.6b02082. Epub 2016 May 4.
J Phys Chem B. 2016.
PMID: 27109703
Free PMC article.
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Uncovering universal rules governing the selectivity of the archetypal DNA glycosylase TDG.
Dodd T, Yan C, Kossmann BR, Martin K, Ivanov I.
Dodd T, et al. Among authors: kossmann br.
Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5974-5979. doi: 10.1073/pnas.1803323115. Epub 2018 May 21.
Proc Natl Acad Sci U S A. 2018.
PMID: 29784784
Free PMC article.
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Alkylpurine glycosylase D employs DNA sculpting as a strategy to extrude and excise damaged bases.
Kossmann B, Ivanov I.
Kossmann B, et al.
PLoS Comput Biol. 2014 Jul 3;10(7):e1003704. doi: 10.1371/journal.pcbi.1003704. eCollection 2014 Jul.
PLoS Comput Biol. 2014.
PMID: 24992034
Free PMC article.
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Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.
Musille PM, Kossmann BR, Kohn JA, Ivanov I, Ortlund EA.
Musille PM, et al. Among authors: kossmann br.
J Biol Chem. 2016 Jan 15;291(3):1411-26. doi: 10.1074/jbc.M115.662874. Epub 2015 Nov 9.
J Biol Chem. 2016.
PMID: 26553876
Free PMC article.
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Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA.
Hudson WH, et al. Among authors: kossmann br.
Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):326-31. doi: 10.1073/pnas.1518960113. Epub 2015 Dec 29.
Proc Natl Acad Sci U S A. 2016.
PMID: 26715749
Free PMC article.
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