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A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.
Kotarsky K, Nilsson NE, Flodgren E, Owman C, Olde B. Kotarsky K, et al. Biochem Biophys Res Commun. 2003 Feb 7;301(2):406-10. doi: 10.1016/s0006-291x(02)03064-4. Biochem Biophys Res Commun. 2003. PMID: 12565875
Differential homing mechanisms regulate regionalized effector CD8alphabeta+ T cell accumulation within the small intestine.
Stenstad H, Svensson M, Cucak H, Kotarsky K, Agace WW. Stenstad H, et al. Among authors: kotarsky k. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10122-7. doi: 10.1073/pnas.0700269104. Epub 2007 Jun 5. Proc Natl Acad Sci U S A. 2007. PMID: 17551016 Free PMC article.
Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes.
Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B. Kotarsky K, et al. J Pharmacol Exp Ther. 2006 Aug;318(2):619-28. doi: 10.1124/jpet.105.098848. Epub 2006 May 1. J Pharmacol Exp Ther. 2006. PMID: 16651401
The binding of LPA to GPR92 was of high affinity (K(D) = 6.4 +/- 0.9 nM) and led to an increase in both phosphoinositide hydrolysis and cAMP production. ...
The binding of LPA to GPR92 was of high affinity (K(D) = 6.4 +/- 0.9 nM) and led to an increase in both phosphoinositide hydrolysis a …
Reverse pharmacology and the de-orphanization of 7TM receptors.
Kotarsky K, Nilsson NE. Kotarsky K, et al. Drug Discov Today Technol. 2004 Oct;1(2):99-104. doi: 10.1016/j.ddtec.2004.07.003. Drug Discov Today Technol. 2004. PMID: 24981378
Developments toward a microfluidic system for long-term monitoring of dynamic cellular events in immobilized human cells.
Davidsson R, Boketoft A, Bristulf J, Kotarsky K, Olde B, Owman C, Bengtsson M, Laurell T, Emnéus J. Davidsson R, et al. Among authors: kotarsky k. Anal Chem. 2004 Aug 15;76(16):4715-20. doi: 10.1021/ac035249o. Anal Chem. 2004. PMID: 15307781
Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors.
Kotarsky K, Nilsson NE, Olde B, Owman C. Kotarsky K, et al. Pharmacol Toxicol. 2003 Dec;93(6):249-58. doi: 10.1111/j.1600-0773.2003.pto930601.x. Pharmacol Toxicol. 2003. PMID: 14675457 Review.
Optimized reporter gene assays based on a synthetic multifunctional promoter and a secreted luciferase.
Kotarsky K, Antonsson L, Owman C, Olde B. Kotarsky K, et al. Anal Biochem. 2003 May 15;316(2):208-15. doi: 10.1016/s0003-2697(03)00082-4. Anal Biochem. 2003. PMID: 12711342
Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids.
Nilsson NE, Kotarsky K, Owman C, Olde B. Nilsson NE, et al. Among authors: kotarsky k. Biochem Biophys Res Commun. 2003 Apr 18;303(4):1047-52. doi: 10.1016/s0006-291x(03)00488-1. Biochem Biophys Res Commun. 2003. PMID: 12684041
Differential inhibition of receptor activation by two mouse monoclonal antibodies specific for the human leukotriene B4 receptor, BLT1.
Sabirsh A, Pettersson A, Boketoft A, Kotarsky K, Owman C. Sabirsh A, et al. Among authors: kotarsky k. Int Immunopharmacol. 2003 Dec;3(13-14):1829-39. doi: 10.1016/j.intimp.2003.08.009. Int Immunopharmacol. 2003. PMID: 14636832
Chronic ethanol exposure enhances activating protein-1 transcriptional activity in human neuroblastoma cells.
Fried U, Kotarsky K, Alling C. Fried U, et al. Among authors: kotarsky k. Alcohol. 2001 Jul;24(3):189-95. doi: 10.1016/s0741-8329(01)00151-3. Alcohol. 2001. PMID: 11557304
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