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23 results

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Page 1
Direct pharmacological targeting of asparagine synthetase to overcome resistance to L-asparaginase in ALL therapy.
Claude R, Srivastava S, Staschke KA, Mellado Fritz CA, Chen S, Liu L, Zhong M, Kothandaraman H, Lanman NA, Davé UP, Batra S, Zhou J, Fang Y, Zhang C, Kapur R, Fan J, Wek RC, Zhang J. Claude R, et al. Among authors: kothandaraman h. JCI Insight. 2026 Jun 4:e203777. doi: 10.1172/jci.insight.203777. Online ahead of print. JCI Insight. 2026. PMID: 42241118 Free article.
Fusobacterium nucleatum produces previously unappreciated AHR-activating metabolites and promotes CRC cell proliferation via the AHR-TERT axis.
Won KJ, Jin PR, Davis L, Orjala J, Armstrong AT, Wang WH, Kothandaraman H, Utturkar SM, Bae D, Jeong BS, Wu C, Murray IA, Perdew GH, Xiang C, Li J, Lee H, Jeong H. Won KJ, et al. Among authors: kothandaraman h. bioRxiv [Preprint]. 2025 Sep 25:2025.09.25.678601. doi: 10.1101/2025.09.25.678601. bioRxiv. 2025. PMID: 41040148 Free PMC article. Preprint.
Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of Scn2a -deficient mice.
Yoo YE, Mandal P, Tang Z, Zhang Z, Zhang J, Chen X, Robinson M, Eaton M, Deming B, Halurkar M, Kothandaraman H, Dabin LC, Jiang B, Gao H, Yuan C, Lanman N, Liu Y, Kim J, Baloni P, Yang Y. Yoo YE, et al. Among authors: kothandaraman h. bioRxiv [Preprint]. 2025 Sep 17:2025.09.16.676420. doi: 10.1101/2025.09.16.676420. bioRxiv. 2025. PMID: 41000929 Free PMC article. Preprint.
Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids.
Olivero-Acosta MI, Robinson M, Que Z, Zhang Z, Harlow HE, Shankar V, Hong S, Wang M, Otterbacher CM, Kadono H, Halurkar M, Kothandaraman H, Lanman N, Nguyen T, Wettschurack K, Zirkle B, Yunis L, Cui N, Chen X, Zhang J, Wu J, Skarnes WC, Yuan C, Guo F, Yang Y. Olivero-Acosta MI, et al. Among authors: kothandaraman h. bioRxiv [Preprint]. 2025 Aug 19:2025.08.18.670956. doi: 10.1101/2025.08.18.670956. bioRxiv. 2025. PMID: 40894722 Free PMC article. Preprint.
Activation of PP2A-B56α leads to aberrant EGFR signaling and proliferative phenotypes in PDAC.
Pfeffer CM, Clifford SJ, Karim SA, Chianis ERD, Heil BN, Gartenhaus LE, Kay EF, Baral G, Hoffman EG, Utturkar SM, Kothandaraman H, Smith-Kinnaman W, Hansen K, Smith EG, Porter E, Zhang F, Lanman NA, Westermarck J, Doud EH, Mosley AL, Morton JP, Allen-Petersen BL. Pfeffer CM, et al. Among authors: kothandaraman h. bioRxiv [Preprint]. 2025 Jul 31:2025.07.18.665598. doi: 10.1101/2025.07.18.665598. bioRxiv. 2025. PMID: 40766646 Free PMC article. Preprint.
Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia.
Broman MM, Lanman NA, Vickman RE, Cresswell GM, Kothandaraman H, Kolliegbo A, Paez JSP, Glaser AP, Helfand BT, Henry G, Strand DW, Franco OE, Hayward SW, Ratliff TL. Broman MM, et al. Among authors: kothandaraman h. Front Immunol. 2025 Jul 7;16:1585446. doi: 10.3389/fimmu.2025.1585446. eCollection 2025. Front Immunol. 2025. PMID: 40692782 Free PMC article.
23 results