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Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci.
Khanshour AM, Kou I, Fan Y, Einarsdottir E, Makki N, Kidane YH, Kere J, Grauers A, Johnson TA, Paria N, Patel C, Singhania R, Kamiya N, Takeda K, Otomo N, Watanabe K, Luk KDK, Cheung KMC, Herring JA, Rios JJ, Ahituv N, Gerdhem P, Gurnett CA, Song YQ, Ikegawa S, Wise CA. Khanshour AM, et al. Among authors: Kou I. Hum Mol Genet. 2018 Nov 15;27(22):3986-3998. doi: 10.1093/hmg/ddy306. Hum Mol Genet. 2018. PMID: 30395268 Free PMC article.
Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture.
Hwang JY, Lee SH, Go MJ, Kim BJ, Kou I, Ikegawa S, Guo Y, Deng HW, Raychaudhuri S, Kim YJ, Oh JH, Kim Y, Moon S, Kim DJ, Koo H, Cha MJ, Lee MH, Yun JY, Yoo HS, Kang YA, Cho EH, Kim SW, Oh KW, Kang MI, Son HY, Kim SY, Kim GS, Han BG, Cho YS, Cho MC, Lee JY, Koh JM. Hwang JY, et al. Among authors: Kou I. J Med Genet. 2013 Apr;50(4):212-9. doi: 10.1136/jmedgenet-2012-101156. Epub 2013 Jan 24. J Med Genet. 2013. PMID: 23349225 Free PMC article.
A multiethnic meta-analysis defined the association of rs12946942 with severe adolescent idiopathic scoliosis.
Takeda K, Kou I, Otomo N, Grauers A, Fan YH, Ogura Y, Takahashi Y, Momozawa Y, Einarsdottir E, Kere J; Japan Scoliosis Clinical Research Group (JSCRG), Matsumoto M, Qiu Y, Song YQ, Gerdhem P, Watanabe K, Ikegawa S. Takeda K, et al. Among authors: Kou I. J Hum Genet. 2019 May;64(5):493-498. doi: 10.1038/s10038-019-0575-7. Epub 2019 Feb 21. J Hum Genet. 2019. PMID: 30787423
A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis.
Ogura Y, Kou I, Takahashi Y, Takeda K, Minami S, Kawakami N, Uno K, Ito M, Yonezawa I, Kaito T, Yanagida H, Watanabe K, Taneichi H, Harimaya K, Taniguchi Y, Kotani T, Tsuji T, Suzuki T, Sudo H, Fujita N, Yagi M, Chiba K, Kubo M, Kamatani Y, Nakamura M, Matsumoto M; Japan Scoliosis Clinical Research Group, Watanabe K, Ikegawa S; Japan Scoliosis Clinical Research Group. Ogura Y, et al. Among authors: Kou I. Hum Mol Genet. 2017 Oct 15;26(20):4086-4092. doi: 10.1093/hmg/ddx291. Hum Mol Genet. 2017. PMID: 29016859
Identification and Functional Characterization of RSPO2 as a Susceptibility Gene for Ossification of the Posterior Longitudinal Ligament of the Spine.
Nakajima M, Kou I, Ohashi H; Genetic Study Group of the Investigation Committee on the Ossification of Spinal Ligaments, Ikegawa S. Nakajima M, et al. Among authors: Kou I. Am J Hum Genet. 2016 Jul 7;99(1):202-7. doi: 10.1016/j.ajhg.2016.05.018. Epub 2016 Jun 30. Am J Hum Genet. 2016. PMID: 27374772 Free PMC article.
A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis.
Ogura Y, Kou I, Miura S, Takahashi A, Xu L, Takeda K, Takahashi Y, Kono K, Kawakami N, Uno K, Ito M, Minami S, Yonezawa I, Yanagida H, Taneichi H, Zhu Z, Tsuji T, Suzuki T, Sudo H, Kotani T, Watanabe K, Hosogane N, Okada E, Iida A, Nakajima M, Sudo A, Chiba K, Hiraki Y, Toyama Y, Qiu Y, Shukunami C, Kamatani Y, Kubo M, Matsumoto M, Ikegawa S. Ogura Y, et al. Among authors: Kou I. Am J Hum Genet. 2015 Aug 6;97(2):337-42. doi: 10.1016/j.ajhg.2015.06.012. Epub 2015 Jul 23. Am J Hum Genet. 2015. PMID: 26211971 Free PMC article.
A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups.
Londono D, Kou I, Johnson TA, Sharma S, Ogura Y, Tsunoda T, Takahashi A, Matsumoto M, Herring JA, Lam TP, Wang X, Tam EM, Song YQ, Fan YH, Chan D, Cheah KS, Qiu X, Jiang H, Huang D; Japanese Scoliosis Clinical Research Group, TSRHC IS Clinical Group, International Consortium for Scoliosis Genetics, Su P, Sham P, Cheung KM, Luk KD, Gordon D, Qiu Y, Cheng J, Tang N, Ikegawa S, Wise CA. Londono D, et al. Among authors: Kou I. J Med Genet. 2014 Jun;51(6):401-6. doi: 10.1136/jmedgenet-2013-102067. Epub 2014 Apr 10. J Med Genet. 2014. PMID: 24721834
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