Kounnas MZ - Search Results

1

Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.

Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Kounnas MZ, et al. Neuron. 2010 Sep 9;67(5):769-80. doi: 10.1016/j.neuron.2010.08.018. Neuron. 2010. PMID: 20826309 Free PMC article.

2

Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.

Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL. Anderson JJ, et al. Among authors: kounnas mz. Biochem Pharmacol. 2005 Feb 15;69(4):689-98. doi: 10.1016/j.bcp.2004.11.015. Epub 2005 Jan 7. Biochem Pharmacol. 2005. PMID: 15670587

3

NGP 555, a γ-secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses.

Kounnas MZ, Durakoglugil MS, Herz J, Comer WT. Kounnas MZ, et al. Alzheimers Dement (N Y). 2019 Nov 25;5:458-467. doi: 10.1016/j.trci.2019.06.006. eCollection 2019. Alzheimers Dement (N Y). 2019. PMID: 31921961 Free PMC article.

4

Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.

Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner SL, Parent AT, Thinakaran G. Gong P, et al. Among authors: kounnas mz. J Biol Chem. 2010 Dec 3;285(49):38042-52. doi: 10.1074/jbc.M110.132613. Epub 2010 Oct 4. J Biol Chem. 2010. PMID: 20921220 Free PMC article.

5

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ, Wagner SL, Troncoso JC, Kawas CH, Katzman R, Koo EH. Kang DE, et al. Among authors: kounnas mz. J Clin Invest. 2000 Nov;106(9):1159-66. doi: 10.1172/JCI11013. J Clin Invest. 2000. PMID: 11067868 Free PMC article.

6

NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease.

Varvel NH, Bhaskar K, Kounnas MZ, Wagner SL, Yang Y, Lamb BT, Herrup K. Varvel NH, et al. Among authors: kounnas mz. J Clin Invest. 2009 Dec;119(12):3692-702. doi: 10.1172/JCI39716. Epub 2009 Nov 9. J Clin Invest. 2009. PMID: 19907078 Free PMC article.

7

NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ_42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents.

Kounnas MZ, Lane-Donovan C, Nowakowski DW, Herz J, Comer WT. Kounnas MZ, et al. Alzheimers Dement (N Y). 2017 Jan;3(1):65-73. doi: 10.1016/j.trci.2016.09.003. Alzheimers Dement (N Y). 2017. PMID: 28497107 Free PMC article.

8

Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.

Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Hiltunen M, et al. Among authors: kounnas mz. J Biol Chem. 2006 Oct 27;281(43):32240-53. doi: 10.1074/jbc.M603106200. Epub 2006 Aug 31. J Biol Chem. 2006. PMID: 16945923 Free article.

9

Kounnas MZ, Moir RD, Rebeck GW, Bush AI, Argraves WS, Tanzi RE, Hyman BT, Strickland DK. Kounnas MZ, et al. Cell. 1995 Jul 28;82(2):331-40. doi: 10.1016/0092-8674(95)90320-8. Cell. 1995. PMID: 7543026 Free article.

10

S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.

Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G. Cheng H, et al. Among authors: kounnas mz. J Biol Chem. 2009 Jan 16;284(3):1373-84. doi: 10.1074/jbc.M806380200. Epub 2008 Nov 20. J Biol Chem. 2009. PMID: 19028695 Free PMC article.

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