Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production.
Okuno T, Koutsogiannaki S, Ohba M, Chamberlain M, Bu W, Lin FY, Eckenhoff RG, Yokomizo T, Yuki K.
Okuno T, et al. Among authors: koutsogiannaki s.
FASEB J. 2017 Apr;31(4):1584-1594. doi: 10.1096/fj.201601095R. Epub 2017 Jan 9.
FASEB J. 2017.
PMID: 28069825
Free PMC article.
Using meta-azi-propofol (AziPm), we photolabeled stable 5-LOX protein, which had been used to solve the X-ray crystallographic structure of 5-LOX, and examined the binding site(s) of propofol on 5-LOX. Two propofol binding pockets were identified near the active site of 5- …
Using meta-azi-propofol (AziPm), we photolabeled stable 5-LOX protein, which had been used to solve the X-ray crystallographic structure of …