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SIRT1 and insulin resistance.
Liang F, Kume S, Koya D. Liang F, et al. Nat Rev Endocrinol. 2009 Jul;5(7):367-73. doi: 10.1038/nrendo.2009.101. Epub 2009 May 19. Nat Rev Endocrinol. 2009. PMID: 19455179 Review.
Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation.
Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S, Isono M, Isshiki K, Uzu T, Kashiwagi A, Koya D. Kume S, et al. Free Radic Biol Med. 2006 Jun 15;40(12):2175-82. doi: 10.1016/j.freeradbiomed.2006.02.014. Epub 2006 Mar 20. Free Radic Biol Med. 2006. PMID: 16785031
SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation.
Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S, Isshiki K, Isono M, Uzu T, Guarente L, Kashiwagi A, Koya D. Kume S, et al. J Biol Chem. 2007 Jan 5;282(1):151-8. doi: 10.1074/jbc.M605904200. Epub 2006 Nov 10. J Biol Chem. 2007. PMID: 17098745
A lack of increase in high molecular weight-adiponectin in macroalbuminuric subjects with metabolic syndrome may exert renal and atherosclerotic risks.
Tsuda S, Nakano S, Konishi K, Koya D. Tsuda S, et al. Diabetes Res Clin Pract. 2008 Mar;79(3):503-9. doi: 10.1016/j.diabres.2007.10.011. Epub 2007 Nov 19. Diabetes Res Clin Pract. 2008. PMID: 18006102
Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes.
Wada T, Ohshima S, Fujisawa E, Koya D, Tsuneki H, Sasaoka T. Wada T, et al. Endocrinology. 2009 Apr;150(4):1662-9. doi: 10.1210/en.2008-1018. Epub 2008 Dec 18. Endocrinology. 2009. PMID: 19095745
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
Kume S, Uzu T, Kashiwagi A, Koya D. Kume S, et al. Endocr Metab Immune Disord Drug Targets. 2010 Mar;10(1):16-24. doi: 10.2174/187153010790827957. Endocr Metab Immune Disord Drug Targets. 2010. PMID: 20044906 Review.
Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet.
Wada T, Kenmochi H, Miyashita Y, Sasaki M, Ojima M, Sasahara M, Koya D, Tsuneki H, Sasaoka T. Wada T, et al. Endocrinology. 2010 May;151(5):2040-9. doi: 10.1210/en.2009-0869. Epub 2010 Mar 8. Endocrinology. 2010. PMID: 20211973
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney.
Kume S, Uzu T, Horiike K, Chin-Kanasaki M, Isshiki K, Araki S, Sugimoto T, Haneda M, Kashiwagi A, Koya D. Kume S, et al. J Clin Invest. 2010 Apr;120(4):1043-55. doi: 10.1172/JCI41376. Epub 2010 Mar 24. J Clin Invest. 2010. PMID: 20335657 Free PMC article.
Acupuncture: is it effective for treatment of insulin resistance?
Liang F, Koya D. Liang F, et al. Diabetes Obes Metab. 2010 Jul;12(7):555-69. doi: 10.1111/j.1463-1326.2009.01192.x. Diabetes Obes Metab. 2010. PMID: 20590731 Review.
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