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The telomerase inhibitor imetelstat alone, and in combination with trastuzumab, decreases the cancer stem cell population and self-renewal of HER2+ breast cancer cells.
Koziel JE, Herbert BS. Koziel JE, et al. Breast Cancer Res Treat. 2015 Feb;149(3):607-18. doi: 10.1007/s10549-015-3270-1. Epub 2015 Jan 28. Breast Cancer Res Treat. 2015. PMID: 25627551 Free PMC article.
Medical genetics and epigenetics of telomerase.
Koziel JE, Fox MJ, Steding CE, Sprouse AA, Herbert BS. Koziel JE, et al. J Cell Mol Med. 2011 Mar;15(3):457-67. doi: 10.1111/j.1582-4934.2011.01276.x. J Cell Mol Med. 2011. PMID: 21323862 Free PMC article. Review.
Phenotypic plasticity in normal breast derived epithelial cells.
Sauder CA, Koziel JE, Choi M, Fox MJ, Grimes BR, Badve S, Blosser RJ, Radovich M, Lam CC, Vaughan MB, Herbert BS, Clare SE. Sauder CA, et al. Among authors: koziel je. BMC Cell Biol. 2014 Jun 10;15:20. doi: 10.1186/1471-2121-15-20. BMC Cell Biol. 2014. PMID: 24915897 Free PMC article.