Kozikowski AP - Search Results

1

Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation.

Smirnova NA, Rakhman I, Moroz N, Basso M, Payappilly J, Kazakov S, Hernandez-Guzman F, Gaisina IN, Kozikowski AP, Ratan RR, Gazaryan IG. Smirnova NA, et al. Among authors: kozikowski ap. Chem Biol. 2010 Apr 23;17(4):380-91. doi: 10.1016/j.chembiol.2010.03.008. Chem Biol. 2010. PMID: 20416509 Free PMC article.

2

Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions.

Sleiman SF, Basso M, Mahishi L, Kozikowski AP, Donohoe ME, Langley B, Ratan RR. Sleiman SF, et al. Among authors: kozikowski ap. Expert Opin Investig Drugs. 2009 May;18(5):573-84. doi: 10.1517/13543780902810345. Expert Opin Investig Drugs. 2009. PMID: 19388875 Free PMC article. Review.

3

HDAC6 is a target for protection and regeneration following injury in the nervous system.

Rivieccio MA, Brochier C, Willis DE, Walker BA, D'Annibale MA, McLaughlin K, Siddiq A, Kozikowski AP, Jaffrey SR, Twiss JL, Ratan RR, Langley B. Rivieccio MA, et al. Among authors: kozikowski ap. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19599-604. doi: 10.1073/pnas.0907935106. Epub 2009 Nov 2. Proc Natl Acad Sci U S A. 2009. PMID: 19884510 Free PMC article.

4

From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.

Gaisina IN, Gallier F, Ougolkov AV, Kim KH, Kurome T, Guo S, Holzle D, Luchini DN, Blond SY, Billadeau DD, Kozikowski AP. Gaisina IN, et al. Among authors: kozikowski ap. J Med Chem. 2009 Apr 9;52(7):1853-63. doi: 10.1021/jm801317h. J Med Chem. 2009. PMID: 19338355 Free PMC article.

5

Structure-guided design of a highly selective glycogen synthase kinase-3β inhibitor: a superior neuroprotective pyrazolone showing antimania effects.

Chen W, Gaisina IN, Gunosewoyo H, Malekiani SA, Hanania T, Kozikowski AP. Chen W, et al. Among authors: kozikowski ap. ChemMedChem. 2011 Sep 5;6(9):1587-92. doi: 10.1002/cmdc.201100231. Epub 2011 Jul 12. ChemMedChem. 2011. PMID: 21751402 Free PMC article. No abstract available.

6

Characterization of maleimide-based glycogen synthase kinase-3 (GSK-3) inhibitors as stimulators of steroidogenesis.

Gunosewoyo H, Midzak A, Gaisina IN, Sabath EV, Fedolak A, Hanania T, Brunner D, Papadopoulos V, Kozikowski AP. Gunosewoyo H, et al. Among authors: kozikowski ap. J Med Chem. 2013 Jun 27;56(12):5115-29. doi: 10.1021/jm400511s. Epub 2013 Jun 17. J Med Chem. 2013. PMID: 23725591 Free PMC article.

7

Highly potent and specific GSK-3beta inhibitors that block tau phosphorylation and decrease alpha-synuclein protein expression in a cellular model of Parkinson's disease.

Kozikowski AP, Gaisina IN, Petukhov PA, Sridhar J, King LT, Blond SY, Duka T, Rusnak M, Sidhu A. Kozikowski AP, et al. ChemMedChem. 2006 Feb;1(2):256-66. doi: 10.1002/cmdc.200500039. ChemMedChem. 2006. PMID: 16892358

8

Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity.

Gaisina IN, Tueckmantel W, Ugolkov A, Shen S, Hoffen J, Dubrovskyi O, Mazar A, Schoon RA, Billadeau D, Kozikowski AP. Gaisina IN, et al. Among authors: kozikowski ap. ChemMedChem. 2016 Jan 5;11(1):81-92. doi: 10.1002/cmdc.201500456. Epub 2015 Nov 23. ChemMedChem. 2016. PMID: 26592932 Free PMC article.

9

Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders.

Kozikowski AP, Gaisina IN, Yuan H, Petukhov PA, Blond SY, Fedolak A, Caldarone B, McGonigle P. Kozikowski AP, et al. J Am Chem Soc. 2007 Jul 4;129(26):8328-32. doi: 10.1021/ja068969w. Epub 2007 Jun 7. J Am Chem Soc. 2007. PMID: 17552518

10

Identification of a glycogen synthase kinase-3β inhibitor that attenuates hyperactivity in CLOCK mutant mice.

Kozikowski AP, Gunosewoyo H, Guo S, Gaisina IN, Walter RL, Ketcherside A, McClung CA, Mesecar AD, Caldarone B. Kozikowski AP, et al. ChemMedChem. 2011 Sep 5;6(9):1593-602. doi: 10.1002/cmdc.201100188. Epub 2011 Jul 5. ChemMedChem. 2011. PMID: 21732538 Free PMC article.

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