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CD4 is active as a signaling molecule on the human monocytic cell line Thp-1.
Graziani-Bowering G, Filion LG, Thibault P, Kozlowski M. Graziani-Bowering G, et al. Among authors: kozlowski m. Exp Cell Res. 2002 Sep 10;279(1):141-52. doi: 10.1006/excr.2002.5581. Exp Cell Res. 2002. PMID: 12213222
HIV and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathways.
Gajanayaka N, O'Hara S, Konarski Y, Fernandes J, Muthumani K, Kozlowski M, Angel JB, Kumar A. Gajanayaka N, et al. Among authors: kozlowski m. J Leukoc Biol. 2017 Sep;102(3):925-939. doi: 10.1189/jlb.4A0716-332RR. Epub 2017 Jul 11. J Leukoc Biol. 2017. PMID: 28698313
SHP-1-Pyk2-Src protein complex and p38 MAPK pathways independently regulate IL-10 production in lipopolysaccharide-stimulated macrophages.
Okenwa C, Kumar A, Rego D, Konarski Y, Nilchi L, Wright K, Kozlowski M. Okenwa C, et al. Among authors: kozlowski m. J Immunol. 2013 Sep 1;191(5):2589-603. doi: 10.4049/jimmunol.1300466. Epub 2013 Jul 31. J Immunol. 2013. PMID: 23904162
Breast cancer cells proliferation is regulated by tyrosine phosphatase SHP1 through c-jun N-terminal kinase and cooperative induction of RFX-1 and AP-4 transcription factors.
Amin S, Kumar A, Nilchi L, Wright K, Kozlowski M. Amin S, et al. Among authors: kozlowski m. Mol Cancer Res. 2011 Aug;9(8):1112-25. doi: 10.1158/1541-7786.MCR-11-0097. Epub 2011 Jun 30. Mol Cancer Res. 2011. PMID: 21719561
Dexamethasone inhibits IL-12p40 production in lipopolysaccharide-stimulated human monocytic cells by down-regulating the activity of c-Jun N-terminal kinase, the activation protein-1, and NF-kappa B transcription factors.
Ma W, Gee K, Lim W, Chambers K, Angel JB, Kozlowski M, Kumar A. Ma W, et al. Among authors: kozlowski m. J Immunol. 2004 Jan 1;172(1):318-30. doi: 10.4049/jimmunol.172.1.318. J Immunol. 2004. PMID: 14688340
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase.
Marsh HN, Dubreuil CI, Quevedo C, Lee A, Majdan M, Walsh GS, Hausdorff S, Said FA, Zoueva O, Kozlowski M, Siminovitch K, Neel BG, Miller FD, Kaplan DR. Marsh HN, et al. Among authors: kozlowski m. J Cell Biol. 2003 Dec 8;163(5):999-1010. doi: 10.1083/jcb.200309036. J Cell Biol. 2003. PMID: 14662744 Free PMC article.
Tumor necrosis factor-alpha induces functionally active hyaluronan-adhesive CD44 by activating sialidase through p38 mitogen-activated protein kinase in lipopolysaccharide-stimulated human monocytic cells.
Gee K, Kozlowski M, Kumar A. Gee K, et al. Among authors: kozlowski m. J Biol Chem. 2003 Sep 26;278(39):37275-87. doi: 10.1074/jbc.M302309200. Epub 2003 Jul 16. J Biol Chem. 2003. PMID: 12867430
Differential regulation of CD44 expression by lipopolysaccharide (LPS) and TNF-alpha in human monocytic cells: distinct involvement of c-Jun N-terminal kinase in LPS-induced CD44 expression.
Gee K, Lim W, Ma W, Nandan D, Diaz-Mitoma F, Kozlowski M, Kumar A. Gee K, et al. Among authors: kozlowski m. J Immunol. 2002 Nov 15;169(10):5660-72. doi: 10.4049/jimmunol.169.10.5660. J Immunol. 2002. PMID: 12421945
Distinct role of p38 and c-Jun N-terminal kinases in IL-10-dependent and IL-10-independent regulation of the costimulatory molecule B7.2 in lipopolysaccharide-stimulated human monocytic cells.
Lim W, Ma W, Gee K, Aucoin S, Nandan D, Diaz-Mitoma F, Kozlowski M, Kumar A. Lim W, et al. Among authors: kozlowski m. J Immunol. 2002 Feb 15;168(4):1759-69. doi: 10.4049/jimmunol.168.4.1759. J Immunol. 2002. PMID: 11823508
Engagement of CD14 sensitizes primary monocytes to IFN-γ to produce IL-12/23p40 and IL-23 through p38 mitogen-activated protein kinase and independent of the janus kinase/signal transducers and activators of transcription signaling.
Blahoianu MA, Rahimi AA, Gajanayaka N, Kozlowski M, Angel JB, Kumar A. Blahoianu MA, et al. Among authors: kozlowski m. J Interferon Cytokine Res. 2013 Aug;33(8):434-45. doi: 10.1089/jir.2012.0058. Epub 2013 May 16. J Interferon Cytokine Res. 2013. PMID: 23679818
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