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Centrosome clustering and chromosomal (in)stability: a matter of life and death.
Krämer A, Maier B, Bartek J. Krämer A, et al. Mol Oncol. 2011 Aug;5(4):324-35. doi: 10.1016/j.molonc.2011.05.003. Epub 2011 May 19. Mol Oncol. 2011. PMID: 21646054 Free PMC article. Review.
New evidence on a phylogenetically conserved mechanism termed 'centrosomal clustering' provides exciting insights into how cells with supernumerary centrosomes adapt to avoid lethal multipolar divisions. ...
New evidence on a phylogenetically conserved mechanism termed 'centrosomal clustering' provides exciting insights into how cells with …
CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity.
Daly OM, Gaboriau D, Karakaya K, King S, Dantas TJ, Lalor P, Dockery P, Krämer A, Morrison CG. Daly OM, et al. Among authors: kramer a. J Cell Sci. 2016 May 1;129(9):1769-74. doi: 10.1242/jcs.186221. Epub 2016 Mar 10. J Cell Sci. 2016. PMID: 26966185
CEP164 is a component of the distal appendages carried by the mother centriole that is required for primary cilium formation. Recent data have implicated CEP164 as a ciliopathy gene and suggest that CEP164 plays some roles in the DNA damage response (DDR). ...
CEP164 is a component of the distal appendages carried by the mother centriole that is required for primary cilium formation. Recent …
DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function.
Löffler H, Bochtler T, Fritz B, Tews B, Ho AD, Lukas J, Bartek J, Krämer A. Löffler H, et al. Among authors: kramer a. Cell Cycle. 2007 Oct 15;6(20):2541-8. doi: 10.4161/cc.6.20.4810. Epub 2007 Jul 30. Cell Cycle. 2007. PMID: 17726372
Forced immobilization of kinase-inactive but not wild-type Chk1 to centrosomes resulted in a G2/M checkpoint defect. Finally, both DNA damage, and forced centrosomal expression of Chk1 in the absence of genotoxic treatments induced centrosome amplification in a subs …
Forced immobilization of kinase-inactive but not wild-type Chk1 to centrosomes resulted in a G2/M checkpoint defect. Finally, both DN …
Structure meets function--centrosomes, genome maintenance and the DNA damage response.
Löffler H, Lukas J, Bartek J, Krämer A. Löffler H, et al. Among authors: kramer a. Exp Cell Res. 2006 Aug 15;312(14):2633-40. doi: 10.1016/j.yexcr.2006.06.008. Epub 2006 Jun 20. Exp Cell Res. 2006. PMID: 16854412 Review.
Centrosomes are cytoplasmic organelles playing a fundamental role in organizing both the interphase cytoskeleton and the bipolar mitotic spindle. ...Moreover, there is growing evidence that a centrosome inactivation checkpoint exists, which utilizes DNA damage-induc …
Centrosomes are cytoplasmic organelles playing a fundamental role in organizing both the interphase cytoskeleton and the bipolar mito …
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.
Krämer A, Mailand N, Lukas C, Syljuåsen RG, Wilkinson CJ, Nigg EA, Bartek J, Lukas J. Krämer A, et al. Nat Cell Biol. 2004 Sep;6(9):884-91. doi: 10.1038/ncb1165. Epub 2004 Aug 15. Nat Cell Biol. 2004. PMID: 15311285
Checking out the centrosome.
Krämer A, Lukas J, Bartek J. Krämer A, et al. Cell Cycle. 2004 Nov;3(11):1390-3. doi: 10.4161/cc.3.11.1252. Epub 2004 Nov 22. Cell Cycle. 2004. PMID: 15483402 Review.
Centrosomes consist of a pair of barrel-shaped microtubule assemblies called centrioles, surrounded by a pericentriolar matrix. ...These assumptions are mainly based on a rapidly growing list of centrosome-associated regulatory proteins such as p53, Brca1, Ch …
Centrosomes consist of a pair of barrel-shaped microtubule assemblies called centrioles, surrounded by a pericentriolar matrix …
Cep63 recruits cdk1 to the centrosome-letter.
Alsara M, Löffler H, Fechter A, Bartek J, Krämer A. Alsara M, et al. Among authors: kramer a. Cancer Res. 2015 Feb 15;75(4):777-8. doi: 10.1158/0008-5472.CAN-14-3431. Epub 2015 Feb 2. Cancer Res. 2015. PMID: 25643699 No abstract available.
Synthesis and structure-activity relationship of griseofulvin analogues as inhibitors of centrosomal clustering in cancer cells.
Rønnest MH, Rebacz B, Markworth L, Terp AH, Larsen TO, Krämer A, Clausen MH. Rønnest MH, et al. Among authors: kramer a. J Med Chem. 2009 May 28;52(10):3342-7. doi: 10.1021/jm801517j. J Med Chem. 2009. PMID: 19402668
Griseofulvin was identified as an inhibitor of centrosomal clustering in a recently developed assay. Centrosomal clustering is an important cellular event that enables bipolar mitosis for cancer cell lines harboring supernumerary centrosomes. ...The most active analogues w …
Griseofulvin was identified as an inhibitor of centrosomal clustering in a recently developed assay. Centrosomal clustering is an imp …
The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.
Castiel A, Danieli MM, David A, Moshkovitz S, Aplan PD, Kirsch IR, Brandeis M, Krämer A, Izraeli S. Castiel A, et al. Among authors: kramer a. J Cell Sci. 2011 Feb 15;124(Pt 4):532-9. doi: 10.1242/jcs.079731. Epub 2011 Jan 18. J Cell Sci. 2011. PMID: 21245198 Free PMC article.
Stil (Sil, SCL/TAL1 interrupting locus) is a cytosolic and centrosomal protein expressed in proliferating cells that is required for mouse and zebrafish neural development and is mutated in familial microcephaly. ...This is the first identification of a negative reg …
Stil (Sil, SCL/TAL1 interrupting locus) is a cytosolic and centrosomal protein expressed in proliferating cells that is required for …
Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.
Löffler H, Fechter A, Matuszewska M, Saffrich R, Mistrik M, Marhold J, Hornung C, Westermann F, Bartek J, Krämer A. Löffler H, et al. Among authors: kramer a. Cancer Res. 2011 Mar 15;71(6):2129-39. doi: 10.1158/0008-5472.CAN-10-2684. Cancer Res. 2011. PMID: 21406398
In a survey of 244 neuroblastoma cases, Cep63 mRNA overexpression was associated with MYCN oncogene amplification and poor prognosis. ...Together, our findings define human Cep63 as a centrosomal recruitment factor for Cdk1 that is essential for mitotic entry, provi …
In a survey of 244 neuroblastoma cases, Cep63 mRNA overexpression was associated with MYCN oncogene amplification and poor prognosis. …
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