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Promoter analysis of Mammalian clock controlled genes.
Bozek K, Kiełbasa SM, Kramer A, Herzel H. Bozek K, et al. Genome Inform. 2007;18:65-74. Genome Inform. 2007. PMID: 18546475
The circadian clock is a biological system providing an internal self-sustained temporal framework and adaptation mechanisms to the daily environmental rhythm. ...The core mammalian circadian clock is a system composed of interacting regulatory feedback loops presen …
The circadian clock is a biological system providing an internal self-sustained temporal framework and adaptation mechanisms to the d …
Modeling feedback loops of the Mammalian circadian oscillator.
Becker-Weimann S, Wolf J, Herzel H, Kramer A. Becker-Weimann S, et al. Biophys J. 2004 Nov;87(5):3023-34. doi: 10.1529/biophysj.104.040824. Epub 2004 Sep 3. Biophys J. 2004. PMID: 15347590 Free PMC article.
The oscillations that are obtained have a 24-h period and are robust toward parameter variations even when the positive feedback is replaced by a constantly expressed activator. ...Moreover, it explains the rhythmic phenotype of Rev-erbalpha-/- mutant mice, where …
The oscillations that are obtained have a 24-h period and are robust toward parameter variations even when the positive feedback is r …
Entrainment in a model of the mammalian circadian oscillator.
Geier F, Becker-Weimann S, Kramer A, Herzel H. Geier F, et al. J Biol Rhythms. 2005 Feb;20(1):83-93. doi: 10.1177/0748730404269309. J Biol Rhythms. 2005. PMID: 15654073
The authors use a mathematical model of the molecular mammalian circadian oscillator to investigate the influence of the free-running period (tau) and the shape of the PRC on the phase of entrainment. They find that a phase-dependent sensitivity ("gating") of light- …
The authors use a mathematical model of the molecular mammalian circadian oscillator to investigate the influence of the free-running …
A model of the mammalian circadian oscillator including the REV-ERBalpha module.
Becker-Weimann S, Wolf J, Kramer A, Herzel H. Becker-Weimann S, et al. Genome Inform. 2004;15(1):3-12. Genome Inform. 2004. PMID: 15712105
Many cellular and physiological processes have been shown to display a rhythm of about 24 hours. This so-called circadian rhythm is based on a system of interlocked negative and positive molecular feedback loops. Here we extend a previous model of the circadi …
Many cellular and physiological processes have been shown to display a rhythm of about 24 hours. This so-called circadian rhythm is b …
Spontaneous synchronization of coupled circadian oscillators.
Gonze D, Bernard S, Waltermann C, Kramer A, Herzel H. Gonze D, et al. Biophys J. 2005 Jul;89(1):120-9. doi: 10.1529/biophysj.104.058388. Epub 2005 Apr 22. Biophys J. 2005. PMID: 15849258 Free PMC article.
We present a dynamical model for the coupling of a population of circadian oscillators in the SCN. The cellular oscillator, a three-variable model, describes the core negative feedback loop of the circadian clock. ...Global coupling is efficient to synchroniz …
We present a dynamical model for the coupling of a population of circadian oscillators in the SCN. The cellular oscillator, …
Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS).
Vanselow K, Vanselow JT, Westermark PO, Reischl S, Maier B, Korte T, Herrmann A, Herzel H, Schlosser A, Kramer A. Vanselow K, et al. Genes Dev. 2006 Oct 1;20(19):2660-72. doi: 10.1101/gad.397006. Epub 2006 Sep 18. Genes Dev. 2006. PMID: 16983144 Free PMC article.
PERIOD (PER) proteins are central components within the mammalian circadian oscillator, and are believed to form a negative feedback complex that inhibits their own transcription at a particular circadian phase. ...In a systematic screen, we have identified 2 …
PERIOD (PER) proteins are central components within the mammalian circadian oscillator, and are believed to form a negative feedback …
CIPC is a mammalian circadian clock protein without invertebrate homologues.
Zhao WN, Malinin N, Yang FC, Staknis D, Gekakis N, Maier B, Reischl S, Kramer A, Weitz CJ. Zhao WN, et al. Nat Cell Biol. 2007 Mar;9(3):268-75. doi: 10.1038/ncb1539. Epub 2007 Feb 18. Nat Cell Biol. 2007. PMID: 17310242
At the core of the mammalian circadian clock is a feedback loop in which the heterodimeric transcription factor CLOCK-Brain, Muscle Arnt-like-1 (BMAL1) drives expression of its negative regulators, periods (PERs) and cryptochromes (CRYs). ...CIPC exhibits circadian regulat …
At the core of the mammalian circadian clock is a feedback loop in which the heterodimeric transcription factor CLOCK-Brain, Muscle A …
Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics.
Reischl S, Vanselow K, Westermark PO, Thierfelder N, Maier B, Herzel H, Kramer A. Reischl S, et al. J Biol Rhythms. 2007 Oct;22(5):375-86. doi: 10.1177/0748730407303926. J Biol Rhythms. 2007. PMID: 17876059
Regulated degradation of circadian clock proteins is a crucial step for rhythm generation per se but also for establishing a normal circadian period. ...Down-regulation of endogenous beta-TrCP1 as well as expression of a dominant-negative form both result in …
Regulated degradation of circadian clock proteins is a crucial step for rhythm generation per se but also for establishing a n …
Molecular insights into human daily behavior.
Brown SA, Kunz D, Dumas A, Westermark PO, Vanselow K, Tilmann-Wahnschaffe A, Herzel H, Kramer A. Brown SA, et al. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1602-7. doi: 10.1073/pnas.0707772105. Epub 2008 Jan 28. Proc Natl Acad Sci U S A. 2008. PMID: 18227513 Free PMC article.
Global parameter search reveals design principles of the mammalian circadian clock.
Locke JC, Westermark PO, Kramer A, Herzel H. Locke JC, et al. BMC Syst Biol. 2008 Feb 29;2:22. doi: 10.1186/1752-0509-2-22. BMC Syst Biol. 2008. PMID: 18312618 Free PMC article.
For example, a remarkable property of the SCN is that the phase of the SCN rhythm resets rapidly after a 'jet lag' type experiment, i.e. when the light/dark (LD) cycle is abruptly advanced or delayed by several hours. ...In addition, we show that when a neuro …
For example, a remarkable property of the SCN is that the phase of the SCN rhythm resets rapidly after a 'jet lag' type experi …
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