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IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP.
Jønsson KL, Laustsen A, Krapp C, Skipper KA, Thavachelvam K, Hotter D, Egedal JH, Kjolby M, Mohammadi P, Prabakaran T, Sørensen LK, Sun C, Jensen SB, Holm CK, Lebbink RJ, Johannsen M, Nyegaard M, Mikkelsen JG, Kirchhoff F, Paludan SR, Jakobsen MR. Jønsson KL, et al. Among authors: krapp c. Nat Commun. 2017 Feb 10;8:14391. doi: 10.1038/ncomms14391. Nat Commun. 2017. PMID: 28186168 Free PMC article.
STING dependent sensing - Does HIV actually care?
Krapp C, Jønsson K, Jakobsen MR. Krapp C, et al. Cytokine Growth Factor Rev. 2018 Apr;40:68-76. doi: 10.1016/j.cytogfr.2018.03.002. Epub 2018 Mar 9. Cytokine Growth Factor Rev. 2018. PMID: 29548644 Review.
IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation.
Hotter D, Bosso M, Jønsson KL, Krapp C, Stürzel CM, Das A, Littwitz-Salomon E, Berkhout B, Russ A, Wittmann S, Gramberg T, Zheng Y, Martins LJ, Planelles V, Jakobsen MR, Hahn BH, Dittmer U, Sauter D, Kirchhoff F. Hotter D, et al. Among authors: krapp c. Cell Host Microbe. 2019 Jun 12;25(6):858-872.e13. doi: 10.1016/j.chom.2019.05.002. Epub 2019 Jun 4. Cell Host Microbe. 2019. PMID: 31175045 Free PMC article.
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.
Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, Paludan SR. Prabakaran T, et al. Among authors: krapp c. EMBO J. 2018 Apr 13;37(8):e97858. doi: 10.15252/embj.201797858. Epub 2018 Mar 1. EMBO J. 2018. PMID: 29496741 Free PMC article.
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming.
Olagnier D, Brandtoft AM, Gunderstofte C, Villadsen NL, Krapp C, Thielke AL, Laustsen A, Peri S, Hansen AL, Bonefeld L, Thyrsted J, Bruun V, Iversen MB, Lin L, Artegoitia VM, Su C, Yang L, Lin R, Balachandran S, Luo Y, Nyegaard M, Marrero B, Goldbach-Mansky R, Motwani M, Ryan DG, Fitzgerald KA, O'Neill LA, Hollensen AK, Damgaard CK, de Paoli FV, Bertram HC, Jakobsen MR, Poulsen TB, Holm CK. Olagnier D, et al. Among authors: krapp c. Nat Commun. 2018 Aug 29;9(1):3506. doi: 10.1038/s41467-018-05861-7. Nat Commun. 2018. PMID: 30158636 Free PMC article.
Human Cytomegalovirus Tegument Protein pp65 (pUL83) Dampens Type I Interferon Production by Inactivating the DNA Sensor cGAS without Affecting STING.
Biolatti M, Dell'Oste V, Pautasso S, Gugliesi F, von Einem J, Krapp C, Jakobsen MR, Borgogna C, Gariglio M, De Andrea M, Landolfo S. Biolatti M, et al. Among authors: krapp c. J Virol. 2018 Feb 26;92(6):e01774-17. doi: 10.1128/JVI.01774-17. Print 2018 Mar 15. J Virol. 2018. PMID: 29263269 Free PMC article.
IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection.
Griffante G, Hewelt-Belka W, Albano C, Gugliesi F, Pasquero S, Castillo Pacheco SF, Bajetto G, Porporato PE, Mina E, Vallino M, Krapp C, Jakobsen MR, Purdy J, von Einem J, Landolfo S, Dell'Oste V, Biolatti M. Griffante G, et al. Among authors: krapp c. mBio. 2022 Jun 28;13(3):e0043522. doi: 10.1128/mbio.00435-22. Epub 2022 Apr 14. mBio. 2022. PMID: 35420480 Free PMC article.
Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses.
McLaren PJ, Gawanbacht A, Pyndiah N, Krapp C, Hotter D, Kluge SF, Götz N, Heilmann J, Mack K, Sauter D, Thompson D, Perreaud J, Rausell A, Munoz M, Ciuffi A, Kirchhoff F, Telenti A. McLaren PJ, et al. Among authors: krapp c. Retrovirology. 2015 May 16;12:41. doi: 10.1186/s12977-015-0165-5. Retrovirology. 2015. PMID: 25980612 Free PMC article.
34 results