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Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats.
Krauskopf A, Blackburn EH. Krauskopf A, et al. Nature. 1996 Sep 26;383(6598):354-7. doi: 10.1038/383354a0. Nature. 1996. PMID: 8848051
Regulation of the overall length of the telomeric DNA repeat tract is likely to be a key requirement for its various biological roles. ...In the related Saccharomyces cerevisiae, the DNA-sequence-specific duplex-binding protein RAP1 is a component of the telomeric c …
Regulation of the overall length of the telomeric DNA repeat tract is likely to be a key requirement for its various biological roles …
The yeast VPS genes affect telomere length regulation.
Rog O, Smolikov S, Krauskopf A, Kupiec M. Rog O, et al. Curr Genet. 2005 Jan;47(1):18-28. doi: 10.1007/s00294-004-0548-y. Epub 2004 Nov 18. Curr Genet. 2005. PMID: 15551135
Eukaryotic cells invest a large proportion of their genome in maintaining telomere length homeostasis. Among the 173 non-essential yeast genes found to affect telomere length, a large proportion is involved in vacuolar traffic. ...Our results indicate that these VPS …
Eukaryotic cells invest a large proportion of their genome in maintaining telomere length homeostasis. Among the 173 non-essential ye …
A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length.
Askree SH, Yehuda T, Smolikov S, Gurevich R, Hawk J, Coker C, Krauskopf A, Kupiec M, McEachern MJ. Askree SH, et al. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8658-63. doi: 10.1073/pnas.0401263101. Epub 2004 May 25. Proc Natl Acad Sci U S A. 2004. PMID: 15161972 Free PMC article.
Telomeres are nucleoprotein structures present at the ends of eukaryotic chromosomes that play a central role in guarding the integrity of the genome by protecting chromosome ends from degradation and fusion. ...To broaden our knowledge about the mechanisms that control te …
Telomeres are nucleoprotein structures present at the ends of eukaryotic chromosomes that play a central role in guarding the integri …
The Rap1p-telomere complex does not determine the replicative capacity of telomerase-deficient yeast.
Smolikov S, Krauskopf A. Smolikov S, et al. Mol Cell Biol. 2003 Dec;23(23):8729-39. doi: 10.1128/mcb.23.23.8729-8739.2003. Mol Cell Biol. 2003. PMID: 14612413 Free PMC article.
In the presence of telomerase, the enzyme that synthesizes telomeric repeats, telomere length is controlled primarily by Rap1p, the budding yeast telomeric DNA binding protein which, through its C-terminal domain, nucleates a protein complex that limits telomere lengthenin …
In the presence of telomerase, the enzyme that synthesizes telomeric repeats, telomere length is controlled primarily by Rap1p, the budding …
ELG1, a regulator of genome stability, has a role in telomere length regulation and in silencing.
Smolikov S, Mazor Y, Krauskopf A. Smolikov S, et al. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1656-61. doi: 10.1073/pnas.0307796100. Epub 2004 Jan 26. Proc Natl Acad Sci U S A. 2004. PMID: 14745004 Free PMC article.
Recently, data have been accumulating to support a role for DNA replication in the control of telomere length, although through a currently poorly understood mechanism. Elg1p, a replication factor C (RFC)-like protein of yeast, contributes to genome stability …
Recently, data have been accumulating to support a role for DNA replication in the control of telomere length, although through a
Telomeres and their control.
McEachern MJ, Krauskopf A, Blackburn EH. McEachern MJ, et al. Annu Rev Genet. 2000;34:331-358. doi: 10.1146/annurev.genet.34.1.331. Annu Rev Genet. 2000. PMID: 11092831 Review.
Role for telomere cap structure in meiosis.
Maddar H, Ratzkovsky N, Krauskopf A. Maddar H, et al. Mol Biol Cell. 2001 Oct;12(10):3191-203. doi: 10.1091/mbc.12.10.3191. Mol Biol Cell. 2001. PMID: 11598202 Free PMC article.
Our results demonstrate that telomeres play a critical role during meiotic division and that their terminal cap structure is essential for this role....
Our results demonstrate that telomeres play a critical role during meiotic division and that their terminal cap structure is essentia …
Molecular manifestations and molecular determinants of telomere capping.
Blackburn EH, Chan S, Chang J, Fulton TB, Krauskopf A, McEachern M, Prescott J, Roy J, Smith C, Wang H. Blackburn EH, et al. Cold Spring Harb Symp Quant Biol. 2000;65:253-63. doi: 10.1101/sqb.2000.65.253. Cold Spring Harb Symp Quant Biol. 2000. PMID: 12760039 Review.
A characteristic of a telomere is that its structural features elicit responses that allow it to be dynamically recapped. Eliciting a DNA damage response through uncapping of a telomere appears to be one way in which telomerase action at that telomere
A characteristic of a telomere is that its structural features elicit responses that allow it to be dynamically recapped. Elic
Mutant telomeres inhibit transcriptional silencing at native telomeres of the yeast Kluyveromyces lactis.
Gurevich R, Smolikov S, Maddar H, Krauskopf A. Gurevich R, et al. Mol Genet Genomics. 2003 Mar;268(6):729-38. doi: 10.1007/s00438-002-0788-9. Epub 2003 Feb 11. Mol Genet Genomics. 2003. PMID: 12655399
We show that K. lactis telomeres are able to repress the transcription of a gene located at the junction between the telomeric repeat tract and the subtelomeric domain. ...C-terminal truncation of the telomere binding protein Rap1p, which leads to a regulated altera …
We show that K. lactis telomeres are able to repress the transcription of a gene located at the junction between the telomeric repeat …
Rap1 protein regulates telomere turnover in yeast.
Krauskopf A, Blackburn EH. Krauskopf A, et al. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12486-91. doi: 10.1073/pnas.95.21.12486. Proc Natl Acad Sci U S A. 1998. PMID: 9770512 Free PMC article.
Telomere length is maintained through a dynamic balance between addition and loss of the terminal telomeric DNA. Normal telomere length regulation requires telomerase as well as a telomeric protein-DNA complex. ...In addition, combining the rap1-DeltaC mutation with …
Telomere length is maintained through a dynamic balance between addition and loss of the terminal telomeric DNA. Normal telomere leng …
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