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A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta.
Pelletier H, Sawaya MR, Wolfle W, Wilson SH, Kraut J. Pelletier H, et al. Among authors: kraut j. Biochemistry. 1996 Oct 1;35(39):12762-77. doi: 10.1021/bi9529566. Biochemistry. 1996. PMID: 8841119
When crystals of human DNA polymerase beta (pol beta) complexed with DNA [Pelletier, H., Sawaya, M. R., Wolfle, W., Wilson, S. H., & Kraut, J. (1996) Biochemistry 35, 12742-12761] are soaked in the presence of dATP and Mn2+, X-ray structural analysis shows that …
When crystals of human DNA polymerase beta (pol beta) complexed with DNA [Pelletier, H., Sawaya, M. R., Wolfle, W., Wilson, S. H., & …
Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta.
Beard WA, Osheroff WP, Prasad R, Sawaya MR, Jaju M, Wood TG, Kraut J, Kunkel TA, Wilson SH. Beard WA, et al. Among authors: kraut j. J Biol Chem. 1996 May 24;271(21):12141-4. doi: 10.1074/jbc.271.21.12141. J Biol Chem. 1996. PMID: 8647805 Free article.
In the crystal structure of a substrate complex, the side chains of residues Asn279, Tyr271, and Arg283 of DNA polymerase beta are within hydrogen bonding distance to the bases of the incoming deoxynucleoside 5'-triphosphate (dNTP), the terminal primer nucleotide, and the templat …
In the crystal structure of a substrate complex, the side chains of residues Asn279, Tyr271, and Arg283 of DNA polymerase beta are within hy …
Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity.
Pelletier H, Sawaya MR, Wolfle W, Wilson SH, Kraut J. Pelletier H, et al. Among authors: kraut j. Biochemistry. 1996 Oct 1;35(39):12742-61. doi: 10.1021/bi952955d. Biochemistry. 1996. PMID: 8841118
In the work reported here, crystal structures of human pol beta complexed with blunt-ended segments of DNA show that, although the crystals belong to a different space group, the DNA is nevertheless bound in the pol beta binding channel in the same way as the DNA in previously re …
In the work reported here, crystal structures of human pol beta complexed with blunt-ended segments of DNA show that, although the crystals …
How do enzymes work?
Kraut J. Kraut J. Science. 1988 Oct 28;242(4878):533-40. doi: 10.1126/science.3051385. Science. 1988. PMID: 3051385 Review.
280 results