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Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.
Peter S, Bultinck J, Myant K, Jaenicke LA, Walz S, Müller J, Gmachl M, Treu M, Boehmelt G, Ade CP, Schmitz W, Wiegering A, Otto C, Popov N, Sansom O, Kraut N, Eilers M. Peter S, et al. EMBO Mol Med. 2014 Dec;6(12):1525-41. doi: 10.15252/emmm.201403927. EMBO Mol Med. 2014. PMID: 25253726 Free PMC article.
A highly selective telomerase inhibitor limiting human cancer cell proliferation.
Damm K, Hemmann U, Garin-Chesa P, Hauel N, Kauffmann I, Priepke H, Niestroj C, Daiber C, Enenkel B, Guilliard B, Lauritsch I, Müller E, Pascolo E, Sauter G, Pantic M, Martens UM, Wenz C, Lingner J, Kraut N, Rettig WJ, Schnapp A. Damm K, et al. EMBO J. 2001 Dec 17;20(24):6958-68. doi: 10.1093/emboj/20.24.6958. EMBO J. 2001. PMID: 11742973 Free PMC article.
Requirement of the mouse I-mfa gene for placental development and skeletal patterning.
Kraut N, Snider L, Chen CM, Tapscott SJ, Groudine M. Kraut N, et al. EMBO J. 1998 Nov 2;17(21):6276-88. doi: 10.1093/emboj/17.21.6276. EMBO J. 1998. PMID: 9799236 Free PMC article.
Key drivers of biomedical innovation in cancer drug discovery.
Huber MA, Kraut N. Huber MA, et al. EMBO Mol Med. 2015 Jan;7(1):12-6. doi: 10.15252/emmm.201404596. EMBO Mol Med. 2015. PMID: 25422355 Free PMC article.
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.
Rathert P, Roth M, Neumann T, Muerdter F, Roe JS, Muhar M, Deswal S, Cerny-Reiterer S, Peter B, Jude J, Hoffmann T, Boryń ŁM, Axelsson E, Schweifer N, Tontsch-Grunt U, Dow LE, Gianni D, Pearson M, Valent P, Stark A, Kraut N, Vakoc CR, Zuber J. Rathert P, et al. Nature. 2015 Sep 24;525(7570):543-547. doi: 10.1038/nature14898. Epub 2015 Sep 14. Nature. 2015. PMID: 26367798 Free PMC article.
Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome.
Grosstessner-Hain K, Hegemann B, Novatchkova M, Rameseder J, Joughin BA, Hudecz O, Roitinger E, Pichler P, Kraut N, Yaffe MB, Peters JM, Mechtler K. Grosstessner-Hain K, et al. Mol Cell Proteomics. 2011 Nov;10(11):M111.008540. doi: 10.1074/mcp.M111.008540. Epub 2011 Aug 21. Mol Cell Proteomics. 2011. PMID: 21857030 Free PMC article.
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.
Lénárt P, Petronczki M, Steegmaier M, Di Fiore B, Lipp JJ, Hoffmann M, Rettig WJ, Kraut N, Peters JM. Lénárt P, et al. Curr Biol. 2007 Feb 20;17(4):304-15. doi: 10.1016/j.cub.2006.12.046. Epub 2007 Feb 8. Curr Biol. 2007. PMID: 17291761
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