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Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle.
Petronczki M, Glotzer M, Kraut N, Peters JM. Petronczki M, et al. Among authors: kraut n. Dev Cell. 2007 May;12(5):713-25. doi: 10.1016/j.devcel.2007.03.013. Dev Cell. 2007. PMID: 17488623
Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases.
Sini P, Gürtler U, Zahn SK, Baumann C, Rudolph D, Baumgartinger R, Strauss E, Haslinger C, Tontsch-Grunt U, Waizenegger IC, Solca F, Bader G, Zoephel A, Treu M, Reiser U, Garin-Chesa P, Boehmelt G, Kraut N, Quant J, Adolf GR. Sini P, et al. Among authors: kraut n. Mol Cancer Ther. 2016 Oct;15(10):2388-2398. doi: 10.1158/1535-7163.MCT-16-0066. Epub 2016 Aug 5. Mol Cancer Ther. 2016. PMID: 27496137
Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia.
Rudolph D, Impagnatiello MA, Blaukopf C, Sommer C, Gerlich DW, Roth M, Tontsch-Grunt U, Wernitznig A, Savarese F, Hofmann MH, Albrecht C, Geiselmann L, Reschke M, Garin-Chesa P, Zuber J, Moll J, Adolf GR, Kraut N. Rudolph D, et al. Among authors: kraut n. J Pharmacol Exp Ther. 2015 Mar;352(3):579-89. doi: 10.1124/jpet.114.221150. Epub 2015 Jan 9. J Pharmacol Exp Ther. 2015. PMID: 25576074
Systematic phosphorylation analysis of human mitotic protein complexes.
Hegemann B, Hutchins JR, Hudecz O, Novatchkova M, Rameseder J, Sykora MM, Liu S, Mazanek M, Lénárt P, Hériché JK, Poser I, Kraut N, Hyman AA, Yaffe MB, Mechtler K, Peters JM. Hegemann B, et al. Among authors: kraut n. Sci Signal. 2011 Nov 8;4(198):rs12. doi: 10.1126/scisignal.2001993. Sci Signal. 2011. PMID: 22067460 Free PMC article.
Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome.
Grosstessner-Hain K, Hegemann B, Novatchkova M, Rameseder J, Joughin BA, Hudecz O, Roitinger E, Pichler P, Kraut N, Yaffe MB, Peters JM, Mechtler K. Grosstessner-Hain K, et al. Among authors: kraut n. Mol Cell Proteomics. 2011 Nov;10(11):M111.008540. doi: 10.1074/mcp.M111.008540. Epub 2011 Aug 21. Mol Cell Proteomics. 2011. PMID: 21857030 Free PMC article.
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.
Lénárt P, Petronczki M, Steegmaier M, Di Fiore B, Lipp JJ, Hoffmann M, Rettig WJ, Kraut N, Peters JM. Lénárt P, et al. Among authors: kraut n. Curr Biol. 2007 Feb 20;17(4):304-15. doi: 10.1016/j.cub.2006.12.046. Epub 2007 Feb 8. Curr Biol. 2007. PMID: 17291761
A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation.
Waizenegger IC, Baum A, Steurer S, Stadtmüller H, Bader G, Schaaf O, Garin-Chesa P, Schlattl A, Schweifer N, Haslinger C, Colbatzky F, Mousa S, Kalkuhl A, Kraut N, Adolf GR. Waizenegger IC, et al. Among authors: kraut n. Mol Cancer Ther. 2016 Mar;15(3):354-65. doi: 10.1158/1535-7163.MCT-15-0617. Epub 2016 Feb 25. Mol Cancer Ther. 2016. PMID: 26916115
BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.
Steegmaier M, Hoffmann M, Baum A, Lénárt P, Petronczki M, Krssák M, Gürtler U, Garin-Chesa P, Lieb S, Quant J, Grauert M, Adolf GR, Kraut N, Peters JM, Rettig WJ. Steegmaier M, et al. Among authors: kraut n. Curr Biol. 2007 Feb 20;17(4):316-22. doi: 10.1016/j.cub.2006.12.037. Epub 2007 Feb 8. Curr Biol. 2007. PMID: 17291758
Molecular requirements for epithelial-mesenchymal transition during tumor progression.
Huber MA, Kraut N, Beug H. Huber MA, et al. Among authors: kraut n. Curr Opin Cell Biol. 2005 Oct;17(5):548-58. doi: 10.1016/ Curr Opin Cell Biol. 2005. PMID: 16098727 Review.
Autocrine PDGFR signaling promotes mammary cancer metastasis.
Jechlinger M, Sommer A, Moriggl R, Seither P, Kraut N, Capodiecci P, Donovan M, Cordon-Cardo C, Beug H, Grünert S. Jechlinger M, et al. Among authors: kraut n. J Clin Invest. 2006 Jun;116(6):1561-70. doi: 10.1172/JCI24652. J Clin Invest. 2006. PMID: 16741576 Free PMC article.
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