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Targeting growth factor receptors with fusion toxins.
Kreitman RJ, FitzGerald D, Pastan I. Kreitman RJ, et al. Int J Immunopharmacol. 1992 Apr;14(3):465-72. doi: 10.1016/0192-0561(92)90177-m. Int J Immunopharmacol. 1992. PMID: 1319965 Review.
Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia.
Kreitman RJ, Chaudhary VK, Kozak RW, FitzGerald DJ, Waldman TA, Pastan I. Kreitman RJ, et al. Blood. 1992 Nov 1;80(9):2344-52. Blood. 1992. PMID: 1421405
Rational design of a chimeric toxin: an intramolecular location for the insertion of transforming growth factor alpha within Pseudomonas exotoxin as a targeting ligand.
Kreitman RJ, Chaudhary VK, Siegall CB, FitzGerald DJ, Pastan I. Kreitman RJ, et al. Bioconjug Chem. 1992 Jan-Feb;3(1):58-62. doi: 10.1021/bc00013a009. Bioconjug Chem. 1992. PMID: 1616950
Properties of chimeric toxins with two recognition domains: interleukin 6 and transforming growth factor alpha at different locations in Pseudomonas exotoxin.
Kreitman RJ, Siegall CB, Chaudhary VK, FitzGerald DJ, Pastan I. Kreitman RJ, et al. Bioconjug Chem. 1992 Jan-Feb;3(1):63-8. doi: 10.1021/bc00013a010. Bioconjug Chem. 1992. PMID: 1616951
Generation of chimeric toxins.
FitzGerald D, Chaudhary VK, Kreitman RJ, Siegall CB, Pastan I. FitzGerald D, et al. Targeted Diagn Ther. 1992;7:447-62. Targeted Diagn Ther. 1992. PMID: 1633306 Review. No abstract available.
The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia.
Kreitman RJ, Chaudhary VK, Waldmann T, Willingham MC, FitzGerald DJ, Pastan I. Kreitman RJ, et al. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8291-5. doi: 10.1073/pnas.87.21.8291. Proc Natl Acad Sci U S A. 1990. PMID: 2236041 Free PMC article.
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