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The multidrug efflux regulator TtgV recognizes a wide range of structurally different effectors in solution and complexed with target DNA: evidence from isothermal titration calorimetry.
Guazzaroni ME, Krell T, Felipe A, Ruiz R, Meng C, Zhang X, Gallegos MT, Ramos JL. Guazzaroni ME, et al. J Biol Chem. 2005 May 27;280(21):20887-93. doi: 10.1074/jbc.M500783200. Epub 2005 Mar 13. J Biol Chem. 2005. PMID: 15767250
Members of the IclR family of bacterial transcriptional regulators function as activators and/or repressors.
Molina-Henares AJ, Krell T, Eugenia Guazzaroni M, Segura A, Ramos JL. Molina-Henares AJ, et al. FEMS Microbiol Rev. 2006 Mar;30(2):157-86. doi: 10.1111/j.1574-6976.2005.00008.x. FEMS Microbiol Rev. 2006. PMID: 16472303 Review.
The TodS-TodT two-component regulatory system recognizes a wide range of effectors and works with DNA-bending proteins.
Lacal J, Busch A, Guazzaroni ME, Krell T, Ramos JL. Lacal J, et al. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8191-6. doi: 10.1073/pnas.0602902103. Epub 2006 May 15. Proc Natl Acad Sci U S A. 2006. PMID: 16702539 Free PMC article.
Different modes of binding of mono- and biaromatic effectors to the transcriptional regulator TTGV: role in differential derepression from its cognate operator.
Guazzaroni ME, Gallegos MT, Ramos JL, Krell T. Guazzaroni ME, et al. J Biol Chem. 2007 Jun 1;282(22):16308-16. doi: 10.1074/jbc.M610032200. Epub 2007 Apr 6. J Biol Chem. 2007. PMID: 17416591
The transcriptional repressor TtgV recognizes a complex operator as a tetramer and induces convex DNA bending.
Guazzaroni ME, Krell T, Gutiérrez del Arroyo P, Vélez M, Jiménez M, Rivas G, Ramos JL. Guazzaroni ME, et al. J Mol Biol. 2007 Jun 15;369(4):927-39. doi: 10.1016/j.jmb.2007.04.022. Epub 2007 Apr 14. J Mol Biol. 2007. PMID: 17482209
Optimization of the palindromic order of the TtgR operator enhances binding cooperativity.
Krell T, Terán W, Mayorga OL, Rivas G, Jiménez M, Daniels C, Molina-Henares AJ, Martínez-Bueno M, Gallegos MT, Ramos JL. Krell T, et al. J Mol Biol. 2007 Jun 22;369(5):1188-99. doi: 10.1016/j.jmb.2007.04.025. Epub 2007 Apr 19. J Mol Biol. 2007. PMID: 17498746
Bacterial sensor kinase TodS interacts with agonistic and antagonistic signals.
Busch A, Lacal J, Martos A, Ramos JL, Krell T. Busch A, et al. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13774-9. doi: 10.1073/pnas.0701547104. Epub 2007 Aug 10. Proc Natl Acad Sci U S A. 2007. PMID: 17693554 Free PMC article.
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